Rilmenidine hemifumarate

Name: Rilmenidine hemifumarate
Brand: tocris
SKU: 0790

Catalog # 0790

Citations (1)

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Key Product Details

Description:	α₂ agonist. Also I₁ ligand
Chemical Name:	2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate
Purity:	≥99% (HPLC)
Molecular Weight:	238.29

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Biological Activity

I₁-imidazoline binding site selective ligand and α₂-adrenoceptor agonist. Possesses greater I₁ vs α₂ selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data

M. Wt	238.29
Formula	C₁₀H₁₆N₂O.½C₄H₄O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	207572-68-7
PubChem ID	45073450
InChi Key	LZFATBMLSYHRTC-WXXKFALUSA-N
Smiles	OC(=O)\C=C\C(O)=O.C1CC1C(NC1=NCCO1)C1CC1.C1CC1C(NC1=NCCO1)C1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.96	25
	ethanol		25
	water	5.96	25

Preparing Stock Solutions

The following data is based on the product molecular weight 238.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	16.79 mL	83.93 mL	167.86 mL
1.25 mM	3.36 mL	16.79 mL	33.57 mL
2.5 mM	1.68 mL	8.39 mL	16.79 mL
12.5 mM	0.34 mL	1.68 mL	3.36 mL

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References

References are publications that support the biological activity of the product.

Bricca Human brain imidazoline receptors: Further characterisation with [³H] clon. Eur.J.Pharmacol. 1994 PMID: 8137880
Bricca Rilmenidine selectivity for imidazoline receptors in human brain. Eur.J.Pharmacol. 1989 PMID: 2566507
Mammoto Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br.J.Pharmacol. 1996 PMID: 8732285
Michel and Ernsberger Keeping an eye on the I site: imidazoline-preferring receptors. TiPS 1992 PMID: 1413085
Williams Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 2008 PMID: 18391949

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Rilmenidine hemifumarate include:

Sánchez-Blázquez et al. (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 130:146
PMID: 10781010

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Rilmenidine hemifumarate

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