Rilmenidine hemifumarate

Name: Rilmenidine hemifumarate
Brand: Tocris Bioscience
SKU: 0790

Catalog # 0790

Citations (1)

COA / SDS

Order Information

Bio-Techne Corporation

tel: (800) 343-7475 (free phone)

tel: (612) 379-2956

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

View Distributors

Key Product Details

Description:	α₂ agonist. Also I₁ ligand
Chemical Name:	2-[N-(Dicyclopropylmethyl)amino]oxazoline hemifumarate
Purity:	≥99% (HPLC)
Molecular Weight:	238.29

View Full Technical Details for Rilmenidine hemifumarate

Complete Your Research

Biological Activity

Rilmenidine hemifumarate is an i₁-imidazoline binding site selective ligand and α₂-adrenoceptor agonist. Possesses greater I₁ vs α₂ selectivity than the prototypical compound, clonidine. Also thought to enhance autophagy; shown to increase LC3-II levels in PC12 cells.

Technical Data

M. Wt	238.29
Formula	C₁₀H₁₆N₂O.½C₄H₄O₄
Storage	Store at -20°C
Purity	≥99% (HPLC)
CAS Number	207572-68-7
PubChem ID	45073450
InChi Key	LZFATBMLSYHRTC-WXXKFALUSA-N
Smiles	OC(=O)\C=C\C(O)=O.C1CC1C(NC1=NCCO1)C1CC1.C1CC1C(NC1=NCCO1)C1CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	5.96	25
	ethanol		25
	water	5.96	25

Preparing Stock Solutions

The following data is based on the product molecular weight 238.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	16.79 mL	83.93 mL	167.86 mL
1.25 mM	3.36 mL	16.79 mL	33.57 mL
2.5 mM	1.68 mL	8.39 mL	16.79 mL
12.5 mM	0.34 mL	1.68 mL	3.36 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References

References are publications that support the biological activity of the product.

Williams Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat.Chem.Biol. 2008 PMID: 18391949
Mammoto Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br.J.Pharmacol. 1996 PMID: 8732285
Bricca Human brain imidazoline receptors: Further characterisation with [³H] clon. Eur.J.Pharmacol. 1994 PMID: 8137880
Michel and Ernsberger Keeping an eye on the I site: imidazoline-preferring receptors. TiPS 1992 PMID: 1413085
Bricca Rilmenidine selectivity for imidazoline receptors in human brain. Eur.J.Pharmacol. 1989 PMID: 2566507

Citations for Rilmenidine hemifumarate (1)

Showing 1 - 1 of 1 citation Showing All

View all citations for the Small Molecules and Peptides platform.

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for Rilmenidine hemifumarate include:

Sánchez-Blázquez et al. (2000) Activation of I(2)-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors. Br J Pharmacol. 130:146
PMID: 10781010

There are no citations that match your criteria.