Retigabine
Tocris Bioscience, part of Bio-Techne | Catalog # 6233
KV7 channel activator
Key Product Details
Description
KV7 channel activator
Alternative Names
Ezogabine
Product Description
Retigabine is a KV7 (KCNQ) channel activator (EC50 values are 0.6 - 100 μM for KV7.1 - KV7.5). Anticonvulsant. Orally bioavailable.Product Specifications
Molecular Weight
303.33
Formula
C16H18FN3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
CAS Number
150812-12-7
PubChem ID
121892
InChI Key
PCOBBVZJEWWZFR-UHFFFAOYSA-N
SMILES
CCOC(NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.33 | 100 | |
| Ethanol | 30.33 | 100 |
Preparing Stock Solutions
for Retigabine
The following data is based on the product molecular weight 303.33
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.30 mL | 16.48 mL | 32.97 mL |
| 5 mM | 0.66 mL | 3.30 mL | 6.59 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.30 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Blackburn-Munro Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 2005 PMID: 15867950
Product Specific Notices for Retigabine
For research use only
Loading...
Loading...
Loading...