Retigabine

Name: Retigabine
Brand: Tocris Bioscience
SKU: 6233
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 6233

(1)

Citations (51)

COA / SDS

KV7 channel activator

Key Product Details

Description:	K_V7 channel activator
Alternative Names:	Ezogabine
Chemical Name:	Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate
Purity:	≥98% (HPLC)
Molecular Weight:	303.33

View Full Technical Details for Retigabine

Technical Data
Citations / Reviews (1)

Biological Activity for Retigabine

Retigabine is a K_V7 (KCNQ) channel activator (EC₅₀ values are 0.6 - 100 μM for K_V7.1 - K_V7.5). Anticonvulsant. Orally bioavailable.

Technical Data for Retigabine

M. Wt	303.33
Formula	C₁₆H₁₈FN₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	150812-12-7
PubChem ID	121892
InChi Key	PCOBBVZJEWWZFR-UHFFFAOYSA-N
Smiles	CCOC(NC1=C(C=C(C=C1)NCC2=CC=C(C=C2)F)N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Retigabine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.33	100
	ethanol	30.33	100

Preparing Stock Solutions for Retigabine

The following data is based on the product molecular weight 303.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.30 mL	16.48 mL	32.97 mL
5 mM	0.66 mL	3.30 mL	6.59 mL
10 mM	0.33 mL	1.65 mL	3.30 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Molarity Calculator

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Dilution Calculator

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Reconstitution Calculator

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References for Retigabine

References are publications that support the biological activity of the product.

Blackburn-Munro Retigabine: chemical synthesis to clinical application. CNS Drug Rev. 2005 PMID: 15867950