RCGD 423

Name: RCGD 423
Brand: Tocris Bioscience
SKU: 7066

Tocris Bioscience a Bio-Techne Brand

Catalog # 7066

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Key Product Details

Description:	gp130 modulator; activates JAK/STAT signaling
Chemical Name:	N-(4-Bromophenyl)-4-phenyl-2-thiazolamine
Purity:	≥98% (HPLC)
Molecular Weight:	331.23

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Biological Activity for RCGD 423

RCGD 423 is a gp130 modulator. Binds gp130, promotes Myc expression, increases lactate production and activates downstream JAK/STAT signaling pathways in hair follicle stem cells. Also increases articular chondrocyte activation and facilitates joint repair by regulating cartilage growth and differentiation.

Compound Libraries for RCGD 423

RCGD 423 is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for RCGD 423

M. Wt	331.23
Formula	C₁₅H₁₁BrN₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	108237-91-8
PubChem ID	4456143
InChi Key	OUFYYVAASPLOAA-UHFFFAOYSA-N
Smiles	BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for RCGD 423

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	33.12	100
	ethanol	33.12	100

Preparing Stock Solutions for RCGD 423

The following data is based on the product molecular weight 331.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.10 mL	30.19 mL
5 mM	0.60 mL	3.02 mL	6.04 mL
10 mM	0.30 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

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References for RCGD 423

References are publications that support the biological activity of the product.

Alam A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS.Chem.Neurosci. 2018 PMID: 29161500
Flores Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat.Cell Biol. 2017 PMID: 28812580

Citations for RCGD 423

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