Rauwolscine hydrochloride

Name: Rauwolscine hydrochloride
Brand: Tocris Bioscience
SKU: 0891

Catalog # 0891

Citations (2)

COA / SDS

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Key Product Details

Description:	α₂ antagonist
Alternative Names:	α-Yohimbine hydrochloride, Corynanthidine
Chemical Name:	17α-Hydroxy-20α-yohimban-16β-carboxylic acid,methyl ester hydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	390.91

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Biological Activity

Rauwolscine hydrochloride is a standard α₂-adrenergic antagonist (K_i values are 3.5, 4.6, and 0.6 nM at cloned human α_2A, α_2B, and α_2C-adrenoceptors respectively). Partial agonist at 5-HT_1A receptors.

Diastereomer also avilable.

Technical Data

M. Wt	390.91
Formula	C₂₁H₂₆N₂O₃.HCl
Storage	Store at RT
Purity	≥95% (HPLC)
CAS Number	6211-32-1
PubChem ID	197067
InChi Key	PIPZGJSEDRMUAW-ZKKXXTDSSA-N
Smiles	[H][C@]12C4=C(C(C=CC=C5)=C5N4)CCN1C[C@]3([H])[C@]([C@H]([C@](OC)=O)[C@@H](O)CC3)([H])C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water		5 with gentle warming
	DMSO	9.77	25 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 390.91.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	10.23 mL	51.16 mL	102.33 mL
1.25 mM	2.05 mL	10.23 mL	20.47 mL
2.5 mM	1.02 mL	5.12 mL	10.23 mL
12.5 mM	0.20 mL	1.02 mL	2.05 mL

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References

References are publications that support the biological activity of the product.

Uhlen [3H]RS79948-197 binding to human, rat, guinea pig and pig α_2A-, α_2B-, and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 1998 PMID: 9551719
Hieble β- and γ-Adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 1995 PMID: 7658428
Arthur Partial agonist properties of rauwolscine and yohimbine for the inhibition of adenylyl cyclase by recombinant human 5-HT_1A receptors. Biochem.Pharmacol. 1993 PMID: 8517875

Citations for Rauwolscine hydrochloride (2)

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Citations are publications that use Bio-Techne products. Selected citations for Rauwolscine hydrochloride include:

Moura et al. (2006) Alpha2-adrenoceptor subtypes involved in the regulation of catecholamine release from the adrenal medulla of mice. Br J Pharmacol. 149:1049
PMID: 17075569
Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. J Neurosci. 24:7745
PMID: 15342742

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