Rasagiline mesylate
Tocris Bioscience, part of Bio-Techne | Catalog # 4308
Selective and irreversible MAO-B inhibitor
Key Product Details
Description
Selective and irreversible MAO-B inhibitor
Product Description
Rasagiline mesylate is a selective irreversible MAO-B inhibitor. Displays antiParkinsonian activity; exhibits neuroprotective and antiapoptotic activity against several neurotoxins in cell culture.Product Specifications
Molecular Weight
267.34
Formula
C12H13N.CH3SO3H
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(1R)-2,3-Dihydro-N-2-propynyl-1H-inden-1-amine methanesulfonate
CAS Number
161735-79-1
PubChem ID
3052775
InChI Key
JDBJJCWRXSVHOQ-UTONKHPSSA-N
SMILES
C#CCN[C@@H]2CCC1=CC=CC=C12.CS(=O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.73 | 100 | |
| DMSO | 26.73 | 100 |
Preparing Stock Solutions
for Rasagiline mesylate
The following data is based on the product molecular weight 267.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.74 mL | 18.70 mL | 37.41 mL |
| 5 mM | 0.75 mL | 3.74 mL | 7.48 mL |
| 10 mM | 0.37 mL | 1.87 mL | 3.74 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.75 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Maruyama The anti-parkinson drug, rasagiline, prevents apoptotic DNA damage induced by peroxynitrite in human DArgic neuroblastoma SH-SY5Y cells. J.Neural Transm. 2002 PMID: 11956966
- Youdim and Weinstock Molecular basis of neuroprotective activities of rasag. and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R)aminoindan-5-YL)-ethyl methyl carbamate]. Cell.Mol.Neurobiol. 2002 PMID: 12043833
- Finberg and Youdim Pharmacological properties of the anti-Parkinson drug rasagiline; modification of endogenous brain amines, rese. reversal, serotonergic and DArgic behaviours. Neuropharmacology 2002 PMID: 12504917
Product Specific Notices for Rasagiline mesylate
For research use only
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