Radicicol

Novus Biologicals, part of Bio-Techne | Catalog # NB110-81566

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NB110-81566
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Product Summary for Radicicol

Hsp90 inhibitor. Synthetic Radicicol, produced by fermentation. White to yellow solid.

Product Specifications

Application Notes

Soluble in DMSO.

Scientific Data Images for Radicicol

Product Image: Radicicol [NB110-81566] - Chemical structure of Radicicol (NB110-81566), a Radicicol. Molecular Formula: C18H17CIO6. Molecular Weight: 364.8 g/mol.

Formulation, Preparation, and Storage

Concentration

Please see the protocols for proper use of this product. If no protocol is available, contact technical services for assistance.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Radicicol

Radicicol inhibits src (IC50 = 0.27 uM) and src-like kinases (1), leading to hypophosphorylation of retinoblastoma tumor suppressor protein (2). It causes morphological reversion of ras-transformed cells (3) and leads to selective depletion of Raf kinase (4). It also displays anti-angiogenic activity (5), and binds to and inhibits Hsp 90 molecular chaperone (6). It binds more strongly to Hsp90 than to GRP94. It also binds to yeast HSP90, E. coli HtpG and TRAP-1.

1. Kwon H.J., et al. (1992) Cancer Res. 52: 6929.
2. Yen A., et al. (1994) Exp.Cell Res. 214: 163.
3. Kwon H.J., et al. (1995) J.Biochem.(Tokyo) 118: 221.
4. Soga S., et al. (1998) J.Biol.Chem. 273: 822.
5. Oikawa T., et al. (1993) Eur.J.Pharmacol. 241: 221.
6. Roe S.M. et al. (1999) J.Med.Chem. 42: 260.

Additional Radicicol Products

Product Documents for Radicicol

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Radicicol

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.

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