RA 2

Product Description

RA 2 is a potent negative modulator of calcium-activated potassium channels K_Ca2.3 and K_Ca3.1 (IC₅₀ values are 2 and 17 nM, respectively), which displays >55-fold selectively for K_Ca2 and K_Ca3.1 over other K_Ca, K_v and K_ir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced K_Ca2/K_Ca3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive K_Ca2 currents. Reduces heart rate in mice in a K_Ca3.1-dependent manner.

Solubility

Preparing Stock Solutions for RA 2

The following data is based on the product molecular weight 414.36

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.41 mL	12.07 mL	24.13 mL
5 mM	0.48 mL	2.41 mL	4.83 mL
10 mM	0.24 mL	1.21 mL	2.41 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Olivan-Viguera Vascular reactivity profile of novel K_Ca3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 2016 PMID: 26821335
• Olivan-Viguera A novel pan-negative-gating modulator of K_Ca2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol.Pharmacol. 2015 PMID: 25468883