(R)-2-Hydroxyglutaric acid disodium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 6124
KDM4A inhibitor; also NF-κB activator
Key Product Details
Description
KDM4A inhibitor; also NF-κB activator
Alternative Names
D-α-hydroxyglutaric acid disodium salt
Product Description
(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).Product Specifications
Molecular Weight
192.08
Formula
C5H6Na2O5
Storage
Store at -20°C
Chemical Name
(R)-2-Hydroxypentanedioic acid disodium salt
CAS Number
103404-90-6
PubChem ID
45489701
InChI Key
DZHFTEDSQFPDPP-HWYNEVGZSA-L
SMILES
O[C@@H](C(O[Na])=O)CCC(O[Na])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 19.21 | 100 |
Preparing Stock Solutions
for (R)-2-Hydroxyglutaric acid disodium salt
The following data is based on the product molecular weight 192.08
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.21 mL | 26.03 mL | 52.06 mL |
| 5 mM | 1.04 mL | 5.21 mL | 10.41 mL |
| 10 mM | 0.52 mL | 2.60 mL | 5.21 mL |
| 50 mM | 0.10 mL | 0.52 mL | 1.04 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Carbonneau The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat.Commun. 2016 PMID: 27624942
- Mauer FTO controls reversible m6Am RNA methylation during snRNA biogenesis. Nat.Chem.Biol. 2019 PMID: 30778204
- Chen The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci.Rep. 2016 PMID: 27577048
Product Specific Notices for (R)-2-Hydroxyglutaric acid disodium salt
For research use only
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