(R)-2-Hydroxyglutaric acid disodium salt

Name: ( R )-2-Hydroxyglutaric acid disodium salt
Brand: Tocris Bioscience
SKU: 6124

Tocris Bioscience, part of Bio-Techne | Catalog # 6124

Citations (6)

COA / SDS

KDM4A inhibitor; also NF-κB activator

Key Product Details

Description:	KDM4A inhibitor; also NF-κB activator
Alternative Names:	D-α-hydroxyglutaric acid disodium salt
Chemical Name:	(R)-2-Hydroxypentanedioic acid disodium salt
Molecular Weight:	192.08

View Full Technical Details for (R)-2-Hydroxyglutaric acid disodium salt

Technical Data
Citations

Biological Activity for (R)-2-Hydroxyglutaric acid disodium salt

(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N⁶-methyladenine demethylase).

Technical Data for (R)-2-Hydroxyglutaric acid disodium salt

M. Wt	192.08
Formula	C₅H₆Na₂O₅
Storage	Store at -20°C
CAS Number	103404-90-6
PubChem ID	45489701
InChi Key	DZHFTEDSQFPDPP-HWYNEVGZSA-L
Smiles	O[C@@H](C(O[Na])=O)CCC(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (R)-2-Hydroxyglutaric acid disodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.21	100

Preparing Stock Solutions for (R)-2-Hydroxyglutaric acid disodium salt

The following data is based on the product molecular weight 192.08.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.21 mL	26.03 mL	52.06 mL
5 mM	1.04 mL	5.21 mL	10.41 mL
10 mM	0.52 mL	2.60 mL	5.21 mL
50 mM	0.10 mL	0.52 mL	1.04 mL

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References for (R)-2-Hydroxyglutaric acid disodium salt

References are publications that support the biological activity of the product.

Carbonneau The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat.Commun. 2016 PMID: 27624942
Mauer FTO controls reversible m⁶Am RNA methylation during snRNA biogenesis. Nat.Chem.Biol. 2019 PMID: 30778204
Chen The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci.Rep. 2016 PMID: 27577048