QX 314 chloride
Tocris Bioscience, part of Bio-Techne | Catalog # 2313
Na+ channel blocker
Key Product Details
Description
Na+ channel blocker
Product Description
QX 314 chloride is a membrane impermeable quaternary derivative of lidocaine, a blocker of voltage-activated Na+ channels.Product Specifications
Molecular Weight
298.85
Formula
C16H27N2OCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride
CAS Number
5369-03-9
PubChem ID
21462
InChI Key
LLPPOMUAOGMYQI-UHFFFAOYSA-N
SMILES
[Cl-].CC[N+](CC)(CC)CC(=O)NC1=C(C)C=CC=C1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30 | 100 |
Preparing Stock Solutions
for QX 314 chloride
The following data is based on the product molecular weight 298.85
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.35 mL | 16.73 mL | 33.46 mL |
| 5 mM | 0.67 mL | 3.35 mL | 6.69 mL |
| 10 mM | 0.33 mL | 1.67 mL | 3.35 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Alreja and Aghajanian QX-314 blocks the potassium but not the sodium dependent components of the opiate response in locus coeruleus neurons. Brain Res. 1994 PMID: 8205485
- Perkins and Wong Intracellular QX-314 blocks the hyperpolarization activated inward current Iq in hippocampal CA1 pyramidal cells. J.Neurophysiol. 1995 PMID: 7760149
- Stichartz The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. J.Gen.Physiol. 1973 PMID: 4541340
Product Specific Notices for QX 314 chloride
For research use only
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