Quipazine dimaleate

Name: Quipazine dimaleate
Brand: tocris
SKU: 0629

Catalog # 0629

Citations (1)

Datasheet / COA / SDS

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Key Product Details

Description:	5-HT₃ agonist
Chemical Name:	2-(1-Piperazinyl)quinoline dimaleate
Purity:	≥99% (HPLC)
Molecular Weight:	445.43

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Biological Activity

Quipazine dimaleate is a selective 5-HT₃ receptor agonist. Also displays antagonist activity at peripheral 5-HT₃ receptors. [³H]-Quipazine labels 5-HT₃ sites in the cortical membranes.

Technical Data

M. Wt	445.43
Formula	C₁₃H₁₅N₃.2C₄H₄O₄
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	150323-78-7
PubChem ID	6420043
InChi Key	VAOSOCRJSSWBEQ-SPIKMXEPSA-N
Smiles	OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C1CN(CCN1)C1=NC2=C(C=CC=C2)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	44.54	100

Preparing Stock Solutions

The following data is based on the product molecular weight 445.43.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.25 mL	11.23 mL	22.45 mL
5 mM	0.45 mL	2.25 mL	4.49 mL
10 mM	0.22 mL	1.12 mL	2.25 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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References

References are publications that support the biological activity of the product.

Ireland and Tyers Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br.J.Pharmacol. 1987 PMID: 3814920
Peroutka and Hamik [³H]Quipazine labels 5-HT₃ recognition sites in rat cortical membranes. Eur.J.Pharmacol. 1988 PMID: 3378579
Sharif Characteristics of 5-HT₃ binding sites in NG108-15, NCB-20 neuroblastoma cells and rat cerebral cortex using [³H]-quipazine and [³H]-GR65630 binding. Br.J.Pharmacol. 1991 PMID: 1830236

Citations (1)

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Citations are publications that use Bio-Techne products. Selected citations for Quipazine dimaleate include:

Hutchinson et al. (2012) Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin. Br J Pharmacol. 37:321
PMID: 21956448

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Product Documents

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

Quipazine dimaleate

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References

Citations (1)

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Certificate of Analysis

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