Quetiapine hemifumarate

Tocris Bioscience, part of Bio-Techne | Catalog # 4735

5-HT2 antagonist; also D2 antagonist; atypical antipsychotic
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Key Product Details

Description

5-HT2 antagonist; also D2 antagonist; atypical antipsychotic

Alternative Names

ICI 204,636

View all Non-selective 5-HT2 Receptor Antagonists »

Product Description

Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.

Product Specifications

Molecular Weight

441.54

Formula

C21H25N3O2S.0.5C4H4O4

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate

CAS Number

111974-72-2

PubChem ID

5281025

InChI Key

ZTHJULTYCAQOIJ-WXXKFALUSA-N

SMILES

OCCOCCN(CC4)CCN4C2=NC1=CC=CC=C1SC3=C2C=CC=C3.O=C(/C=C/C(O)=O)O.OCCOCCN(CC8)CCN8C6=NC5=CC=CC=C5SC7=C6C=CC=C7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.08 50

Preparing Stock Solutions for Quetiapine hemifumarate

The following data is based on the product molecular weight 441.54

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.53 mL 22.65 mL 45.30 mL
2.5 mM 0.91 mL 4.53 mL 9.06 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
25 mM 0.09 mL 0.45 mL 0.91 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Quetiapine hemifumarate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Quetiapine hemifumarate

For research use only

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