Quetiapine hemifumarate

Name: Quetiapine hemifumarate
Brand: Tocris Bioscience
SKU: 4735

Tocris Bioscience, part of Bio-Techne | Catalog # 4735

COA / SDS

5-HT2 antagonist; also D2 antagonist; atypical antipsychotic

Key Product Details

Description:	5-HT₂ antagonist; also D₂ antagonist; atypical antipsychotic
Alternative Names:	ICI 204,636
Chemical Name:	2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
Purity:	≥98% (HPLC)
Molecular Weight:	441.54

View Full Technical Details for Quetiapine hemifumarate

Technical Data
Citations

Biological Activity for Quetiapine hemifumarate

Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT₂) and dopamine (D₂) receptors (IC₅₀ values are 148 and 329 nM respectively). Lacks affinity at either D₁ or muscarinic receptors.

Compound Libraries for Quetiapine hemifumarate

Quetiapine hemifumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Quetiapine hemifumarate

M. Wt	441.54
Formula	C₂₁H₂₅N₃O₂S.0.5C₄H₄O₄
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	111974-72-2
PubChem ID	5281025
InChi Key	ZTHJULTYCAQOIJ-WXXKFALUSA-N
Smiles	OCCOCCN(CC4)CCN4C2=NC1=CC=CC=C1SC3=C2C=CC=C3.O=C(/C=C/C(O)=O)O.OCCOCCN(CC8)CCN8C6=NC5=CC=CC=C5SC7=C6C=CC=C7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Quetiapine hemifumarate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	22.08	50

Preparing Stock Solutions for Quetiapine hemifumarate

The following data is based on the product molecular weight 441.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.53 mL	22.65 mL	45.30 mL
2.5 mM	0.91 mL	4.53 mL	9.06 mL
5 mM	0.45 mL	2.26 mL	4.53 mL
25 mM	0.09 mL	0.45 mL	0.91 mL

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References for Quetiapine hemifumarate

References are publications that support the biological activity of the product.

Ellenbroek Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz. Neuropsychopharmacology 1996 PMID: 8887995
Saller and Salama Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 1993 PMID: 7871032