QS 11
Tocris Bioscience, part of Bio-Techne | Catalog # 3324
ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Key Product Details
Description
ARFGAP1 inhibitor; modulates Wnt/β-catenin signaling
Product Description
QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells.Product Specifications
Molecular Weight
567.68
Formula
C36H33N5O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-[2-(Indan-5-yloxy)-9-(1,1'-biphenyl-4-yl)methyl)-9H-purin-6-ylamino]-3-phenyl-propan-1-ol
CAS Number
944328-88-5
PubChem ID
42623900
InChI Key
DOKZLKDGUQWMSX-HKBQPEDESA-N
SMILES
OC[C@H](CC6=CC=CC=C6)NC1=C2C(N(CC3=CC=C(C7=CC=CC=C7)C=C3)C=N2)=NC(OC4=CC=C(CCC5)C5=C4)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.77 | 100 | |
| Ethanol | 56.77 | 100 |
Preparing Stock Solutions
for QS 11
The following data is based on the product molecular weight 567.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.76 mL | 8.81 mL | 17.62 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.76 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Emre A chemical approach to stem cell biology Curr.Opin.Chem.Biol. 2007 PMID: 17493865
- Zhang Small-molecule synergist of the Wnt/β-catenin signaling pathway. Proc.Natl.Acad.Sci.USA 2007 PMID: 17460038
Product Specific Notices for QS 11
For research use only
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