QO 58

Tocris Bioscience, part of Bio-Techne | Catalog # 5083

Kv7 channel opener
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Key Product Details

Description

Kv7 channel opener

View all Voltage-gated Potassium Channel Activators »

Product Description

QO 58 is a Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.

Product Specifications

Molecular Weight

443.18

Formula

C18H8Cl2F4N4O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one

CAS Number

1259536-62-3

PubChem ID

51351551

InChI Key

ZOLHKPWSDFSDKA-UHFFFAOYSA-N

SMILES

O=C1C=C(C4=CC(F)=C(Cl)N=C4Cl)NC2=C(C3=CC=CC=C3)C(C(F)(F)F)=NN12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.16 50

Preparing Stock Solutions for QO 58

The following data is based on the product molecular weight 443.18

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.51 mL 22.56 mL 45.13 mL
2.5 mM 0.90 mL 4.51 mL 9.03 mL
5 mM 0.45 mL 2.26 mL 4.51 mL
25 mM 0.09 mL 0.45 mL 0.90 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for QO 58

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for QO 58

For research use only

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