Pyridostatin pentahydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 4763

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest
Discontinued Product
4763 has been discontinued. View all Cell Cycle Inhibitors products.

Key Product Details

Description

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

View all Cell Cycle Inhibitors »

Product Description

Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd = 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, inducing telomerase dysfunction. Activates the DNA-dependent protein kinase catalytic sunbunit (DNA-PKcs).

Product Specifications

Molecular Weight

778.94

Formula

C31H32N8O5.5HCl

Storage

Desiccate at RT

Purity

≥95% (HPLC)

Chemical Name

4-(2-Aminoethoxy)N2,N6-bis[(4-(2-aminoethoxy)-2-quinolinyl]-2,6-pyridinecarboxamide pentahydrochloride

CAS Number

1781882-65-2

PubChem ID

78243739

InChI Key

SRIZPFGTXSQRFM-UHFFFAOYSA-N

SMILES

NCCOC1=CC(C(NC2=NC(C=CC=C3)=C3C(OCCN)=C2)=O)=NC(C(NC4=CC(OCCN)=C(C=CC=C5)C5=N4)=O)=C1.Cl.Cl.Cl.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 15.58 20

Preparing Stock Solutions for Pyridostatin pentahydrochloride

The following data is based on the product molecular weight 778.94

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.42 mL 32.09 mL 64.19 mL
1 mM 1.28 mL 6.42 mL 12.84 mL
2 mM 0.64 mL 3.21 mL 6.42 mL
10 mM 0.13 mL 0.64 mL 1.28 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Pyridostatin pentahydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Pyridostatin pentahydrochloride

For research use only

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