PX 12

Tocris Bioscience, part of Bio-Techne | Catalog # 2954

Thioredoxin-1 inhibitor
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Key Product Details

Description

Thioredoxin-1 inhibitor

Alternative Names

IV-2

View all Thioredoxin Reductase Inhibitors »

Product Description

PX 12 is a thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

Product Specifications

Molecular Weight

188.31

Formula

C7H12N2S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(1-Methylpropyl)dithio]-1H-imidazole

CAS Number

141400-58-0

PubChem ID

219104

InChI Key

BPBPYQWMFCTCNG-UHFFFAOYSA-N

SMILES

CC(CC)SSC1=NC=CN1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.83 100

Preparing Stock Solutions for PX 12

The following data is based on the product molecular weight 188.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.31 mL 26.55 mL 53.10 mL
5 mM 1.06 mL 5.31 mL 10.62 mL
10 mM 0.53 mL 2.66 mL 5.31 mL
50 mM 0.11 mL 0.53 mL 1.06 mL

Calculators

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Product Documents for PX 12

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PX 12

For research use only

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