Purvalanol A
Tocris Bioscience, part of Bio-Techne | Catalog # 1580
Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Key Product Details
Description
Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5
Alternative Names
NG 60
Product Description
Purvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC50 values are 4, 4 - 70, 75 - 240 and 100 nM for cdk1, cdk2, cdk5 and cdk 7, respectively). Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.Licensing Information
Sold under license from the Regents of the University of CaliforniaProduct Specifications
Molecular Weight
388.90
Formula
C19H25ClN6O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol
CAS Number
212844-53-6
PubChem ID
456214
InChI Key
PMXCMJLOPOFPBT-HNNXBMFYSA-N
SMILES
ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.89 | 100 | |
| Ethanol | 19.45 | 50 |
Preparing Stock Solutions
for Purvalanol A
The following data is based on the product molecular weight 388.90
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.86 mL | 25.71 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.29 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jorda How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 2018 PMID: 30234987
- Villerbu Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int.J.Cancer 2002 PMID: 11857351
- Gray Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 1998 PMID: 9677190
- Gray ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 1999 PMID: 10495356
- Bain The specificities of protein kinase inhibitors: an update. Biochem.J. 2003 PMID: 12534346
Product Specific Notices for Purvalanol A
For research use only
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