PSEM 89S

Name: PSEM 89S
Brand: Tocris Bioscience
SKU: 6426

Tocris Bioscience, part of Bio-Techne | Catalog # 6426

Citations (5)

COA / SDS

PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist

Key Product Details

Description:	PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ chimeric ion channel agonist
Chemical Name:	N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
Purity:	≥98% (HPLC)
Molecular Weight:	404.38

View Full Technical Details for PSEM 89S

Technical Data
Citations

Biological Activity for PSEM 89S

PSEM 89S is a PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ chimeric ion channel agonist (EC₅₀ values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAM^L141F,Y115F-5-HT₃ chimeric ion channels and inhibits activity of neurons expressing PSAM^L141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAM^L141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant.

Plasmid vectors for the transfection of cells with PSAM^L141F-GlyR and PSAM^L141F,Y115F-5-HT₃ are available from Addgene.

Licensing Information

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.

Technical Data for PSEM 89S

M. Wt	404.38
Formula	C₁₆H₂₂N₂O₃.CF₃CO₂H
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1336913-03-1
PubChem ID	134812840
InChi Key	GLKCNNXBIUCCJJ-PFEQFJNWSA-N
Smiles	OC(C(F)(F)F)=O.O=C(N[C@@H]1CN2CCC1CC2)C(C=C3OC)=C(C=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSEM 89S

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	40.44	100
	water	40.44	100

Preparing Stock Solutions for PSEM 89S

The following data is based on the product molecular weight 404.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.47 mL	12.36 mL	24.73 mL
5 mM	0.49 mL	2.47 mL	4.95 mL
10 mM	0.25 mL	1.24 mL	2.47 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for PSEM 89S

References are publications that support the biological activity of the product.

Cerritelli Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea. PLoS One 2016 PMID: 27077912
Magnus Chemical and genetic engineering of selective ion channel-ligand interactions. Science 2011 PMID: 21885782