PSB CB5
Tocris Bioscience, part of Bio-Techne | Catalog # 6372
Selective GPR18 antagonist
Product Description
PSB CB5 is a selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine (Cat. No. 1445) induced acrosomal exocytosis in human spermatozoa.Product Specifications
Molecular Weight
384.88
Formula
C20H17ClN2O2S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
CAS Number
1627710-30-8
PubChem ID
85469571
InChI Key
XJBQRMOGMULGPP-PDGQHHTCSA-N
SMILES
O=C(N1C(SCCC1)=N/2)C2=C\C3=CC(OCC4=CC=C(Cl)C=C4)=CC=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.7 | 20 |
Preparing Stock Solutions
for PSB CB5
The following data is based on the product molecular weight 384.88
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.99 mL | 64.96 mL | 129.91 mL |
| 1 mM | 2.60 mL | 12.99 mL | 25.98 mL |
| 2 mM | 1.30 mL | 6.50 mL | 12.99 mL |
| 10 mM | 0.26 mL | 1.30 mL | 2.60 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Flegel Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 2016 PMID: 27572937
- Rempel Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm.
Product Specific Notices for PSB CB5
For research use only
Loading...
Loading...