PSB 603

Catalog # 3198 | Tocris Bioscience a Bio-Techne Brand

Highly selective A2B antagonist

Key Product Details

Description:	Highly selective A_2B antagonist
Chemical Name:	8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity:	≥98% (HPLC)
Molecular Weight:	529.01

View Full Technical Details for PSB 603

Technical Data
Citations (6) / Reviews

Biological Activity for PSB 603

PSB 603 is an adenosine A_2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (K_i values are 0.553, > 10000, > 10000 and > 10000 nM for A_2B, A₁, A_2A and A₃ receptors respectively).

Compound Libraries for PSB 603

PSB 603 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSB 603

M. Wt	529.01
Formula	C₂₄H₂₅ClN₆O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1092351-10-4
PubChem ID	44185871
InChi Key	OVHCTHHFOHMNFV-UHFFFAOYSA-N
Smiles	O=C(NC2=C1NC(C3=CC=C(S(N4CCN(C5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB 603

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.45	50

Preparing Stock Solutions for PSB 603

The following data is based on the product molecular weight 529.01.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.78 mL	18.90 mL	37.81 mL
2.5 mM	0.76 mL	3.78 mL	7.56 mL
5 mM	0.38 mL	1.89 mL	3.78 mL
25 mM	0.08 mL	0.38 mL	0.76 mL

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References for PSB 603

References are publications that support the biological activity of the product.

Borrmann 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 2009 PMID: 19569717

Citations for PSB 603 (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for PSB 603 include:

Kang et al. (2016) Small molecule-driven direct conversion of human pluripotent stem cells into functional osteoblasts. Sci Adv. 2:e1600691
PMID: 27602403
Stoddart et al. (2015) Application of BRET to monitor ligand binding to GPCRs. Nat Methods. 12:661
PMID: 26030448
Rao et al. (2015) Adenosine Signaling Mediates Osteogenic Differentiation of Human Embryonic Stem Cells on Mineralized Matrices. Front Bioeng Biotechnol. 3:185
PMID: 26618155
Schneider et al. (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Oncogene. 14:201
PMID: 26597723
Long et al. (2015) p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death. J Pharmacol Exp Ther. 34:5152
PMID: 25659586
Ham et al. (2010) Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. Proc Natl Acad Sci U S A. 335:607
PMID: 20805305

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