PSB 603
Tocris Bioscience, part of Bio-Techne | Catalog # 3198
Highly selective A2B antagonist
Key Product Details
Description
Highly selective A2B antagonist
Product Description
PSB 603 is an adenosine A2B receptor antagonist that displays > 17000-fold selectivity over other adenosine receptors (Ki values are 0.553, > 10000, > 10000 and > 10000 nM for A2B, A1, A2A and A3 receptors respectively). Downregulates the expression of osteocalcin and osteopontin during osteogenic differentiation of mesenchymal stem cells.Product Specifications
Molecular Weight
529.01
Formula
C24H25ClN6O4S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
8-[4-[4-(4-Chlorophenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
CAS Number
1092351-10-4
PubChem ID
44185871
InChI Key
OVHCTHHFOHMNFV-UHFFFAOYSA-N
SMILES
O=C(NC2=C1NC(C3=CC=C(S(N4CCN(C5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.45 | 50 |
Preparing Stock Solutions
for PSB 603
The following data is based on the product molecular weight 529.01
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.78 mL | 18.90 mL | 37.81 mL |
| 2.5 mM | 0.76 mL | 3.78 mL | 7.56 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 25 mM | 0.08 mL | 0.38 mL | 0.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shih Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling. Proc.Natl.Acad.Sci.U.S.A. 2014 PMID: 24395775
- Borrmann 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 2009 PMID: 19569717
Product Specific Notices for PSB 603
For research use only
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