PSB 10 hydrochloride

Product Description

PSB 10 hydrochloride is a potent and highly selective antagonist for the human adenosine A₃ receptor, with low affinity for the rat A₃ receptor (K_i values are 0.44 and > 17000 nM respectively). Displays > 3800-fold selectivity over human A₁, A_2A and A_2B receptors (K_i values are 4.1, 3.3 and 30 μM respectively) and > 1800-fold selectivity over rat A₁ and A_2A receptors. Acts as an inverse agonist in the [³⁵S]GTPγS binding assay in hA₃-CHO cells (IC₅₀ = 4 nM). Produces thermal hyperalgesia in mice in vivo.

Solubility

Preparing Stock Solutions for PSB 10 hydrochloride

The following data is based on the product molecular weight 435.14

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.19 mL	45.96 mL	91.92 mL
1.25 mM	1.84 mL	9.19 mL	18.38 mL
2.5 mM	0.92 mL	4.60 mL	9.19 mL
12.5 mM	0.18 mL	0.92 mL	1.84 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ozola 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A₃ adenosine receptors. Bioorg.Med.Chem. 2003 PMID: 12517430
• Abo-Salem Antinociceptive effects of novel A_2B adenosine receptor antagonists. J.Pharmacol.Exp.Ther. 2004 PMID: 14563788
• Muller Medicinal chemistry of adenosine A₃ receptor ligands. Curr.Top.Med.Chem. 2003 PMID: 12570761