PSB 0788

Name: PSB 0788
Brand: Tocris Bioscience
SKU: 3199

Tocris Bioscience a Bio-Techne Brand

Catalog # 3199

Citations (2)

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Key Product Details

Description:	Selective A_2B antagonist
Chemical Name:	8-[4-[4-(4-Chlorobenzyl)piperazide-1-sulfonyl)phenyl]]-1-propylxanthine
Purity:	≥98% (HPLC)
Molecular Weight:	543.04

View Full Technical Details for PSB 0788

Biological Activity for PSB 0788

PSB 0788 is a potent and selective adenosine A_2B receptor antagonist (IC₅₀ = 3.64 nM at human A_2B receptors). Displays > 100-fold selectivity over hA₁, hA_2A and hA₃ receptors.

Compound Libraries for PSB 0788

PSB 0788 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSB 0788

M. Wt	543.04
Formula	C₂₅H₂₇ClN₆O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1027513-54-7
PubChem ID	44186581
InChi Key	JQZJACVYMPKVDS-UHFFFAOYSA-N
Smiles	O=C(NC2=C1NC(C3=CC=C(S(N4CCN(CC5=CC=C(Cl)C=C5)CC4)(=O)=O)C=C3)=N2)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB 0788

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	54.3	100

Preparing Stock Solutions for PSB 0788

The following data is based on the product molecular weight 543.04.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.84 mL	9.21 mL	18.41 mL
5 mM	0.37 mL	1.84 mL	3.68 mL
10 mM	0.18 mL	0.92 mL	1.84 mL
50 mM	0.04 mL	0.18 mL	0.37 mL

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References for PSB 0788

References are publications that support the biological activity of the product.

Borrmann 1-alkyl-8-(piperazine-1-sulfonyl)phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J.Med.Chem. 2009 PMID: 19569717

Citations for PSB 0788 (2)

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Citations are publications that use Bio-Techne products. Selected citations for PSB 0788 include:

Al-Taei et al. (2017) Prostaglandin E2-mediated adenosinergic effects on CD14+ cells: Self-amplifying immunosuppression in cancer. Oncoimmunology. 6:e1268308
PMID: 28344879
Wakisaka et al. (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol. 27:1437
PMID: 28502661

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Product Documents for PSB 0788

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.