PSB 0777 ammonium salt

Name: PSB 0777 ammonium salt
Brand: Tocris Bioscience
SKU: 4334

Tocris Bioscience, part of Bio-Techne | Catalog # 4334

Citations (1)

COA / SDS

Potent adenosine A2A agonist

Key Product Details

Description:	Potent adenosine A_2A agonist
Chemical Name:	4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt
Purity:	≥97% (HPLC)
Molecular Weight:	500.55

View Full Technical Details for PSB 0777 ammonium salt

Technical Data
Citations

Biological Activity for PSB 0777 ammonium salt

PSB 0777 ammonium salt is a potent adenosine A_2A receptor full agonist (K_i = 44.4 nM for rat brain striatal A_2A receptors). Exhibits subtype selectivity for A_2A receptors over A₁, A_2B and A₃ receptors (K_i ≥ 10 000 nM for rat A₁, human A_2B and human A₃ receptors). Potentiates acetylcholine-induced contractions in ex vivo rat ileum/jejunum segments.

Compound Libraries for PSB 0777 ammonium salt

PSB 0777 ammonium salt is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PSB 0777 ammonium salt

M. Wt	500.55
Formula	C₁₈H₂₀N₅O₇S₂.NH₄
Storage	Store at RT
Purity	≥97% (HPLC)
CAS Number	2122196-16-9
PubChem ID	90488932
InChi Key	AYQGFWKUGKSGCZ-VSAOVUCUSA-N
Smiles	NC1=C3C(N([C@@H]4O[C@H](CO)[C@@H](O)[C@@H]4O)C=N3)=NC(SCCC2=CC=C(S(=O)(O)=O)C=C2)=N1.N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB 0777 ammonium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	50.05	100
	DMSO	50.05	100

Preparing Stock Solutions for PSB 0777 ammonium salt

The following data is based on the product molecular weight 500.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.00 mL	9.99 mL	19.98 mL
5 mM	0.40 mL	2.00 mL	4.00 mL
10 mM	0.20 mL	1.00 mL	2.00 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

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Reconstitution Calculator

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References for PSB 0777 ammonium salt

References are publications that support the biological activity of the product.

El-Tayeb Development of polar adenosine A_2A receptor agonists for inflammatory bowel disease: synergism with A_2B antagonists. ACS Med.Chem.Lett. 2012 PMID: 24900277