PSB 0777 ammonium salt
Tocris Bioscience, part of Bio-Techne | Catalog # 4334
Potent adenosine A2A agonist
Key Product Details
Description
Potent adenosine A2A agonist
Product Description
PSB 0777 ammonium salt is a potent adenosine A2A receptor full agonist (Ki = 44.4 nM for rat brain striatal A2A receptors). Exhibits subtype selectivity for A2A receptors over A1, A2B and A3 receptors (Ki ≥ 10 000 nM for rat A1, human A2B and human A3 receptors). Potentiates acetylcholine-induced contractions in ex vivo rat ileum/jejunum segments.Product Specifications
Molecular Weight
500.55
Formula
C18H20N5O7S2.NH4
Storage
Store at RT
Purity
≥97% (HPLC)
Chemical Name
4-[2-[(6-Amino-9-b-D-ribofuranosyl-9H-purin-2-yl)thio]ethyl]benzenesulfonic acid ammonium salt
CAS Number
2122196-16-9
PubChem ID
90488932
InChI Key
AYQGFWKUGKSGCZ-VSAOVUCUSA-N
SMILES
NC1=C3C(N([C@@H]4O[C@H](CO)[C@@H](O)[C@@H]4O)C=N3)=NC(SCCC2=CC=C(S(=O)(O)=O)C=C2)=N1.N
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.05 | 100 | |
| DMSO | 50.05 | 100 |
Preparing Stock Solutions
for PSB 0777 ammonium salt
The following data is based on the product molecular weight 500.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.00 mL | 9.99 mL | 19.98 mL |
| 5 mM | 0.40 mL | 2.00 mL | 4.00 mL |
| 10 mM | 0.20 mL | 1.00 mL | 2.00 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.40 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- El-Tayeb Development of polar adenosine A2A receptor agonists for inflammatory bowel disease: synergism with A2B antagonists. ACS Med.Chem.Lett. 2012 PMID: 24900277
Product Specific Notices for PSB 0777 ammonium salt
For research use only
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