Highly potent P2Y12 antagonist
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Key Product Details
Description: | Highly potent P2Y12 antagonist |
Chemical Name: | 1-Amino-9,10-dihydro-9,10-dioxo-4-[[4-(phenylamino)-3-sulfophenyl]amino]-2-anthracenesulfonic acid sodium salt |
Purity: | ≥95% (HPLC) |
Molecular Weight: | 609.54 |
Citations for PSB 0739 (15)
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Citations are publications that use Bio-Techne products. Selected citations for PSB 0739 include:
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Domokos et al.
(2022)
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions.
J Exp Med.
219
PMID: 35201268 -
Tibor et al.
(2022)
The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets.
Pharmacol Res.
176:106045
PMID: 34968684 -
Stefano L et al.
(2022)
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
Elife.
11
PMID: 35191835 -
Mária et al.
(2021)
Involvement of P2Y12 receptors in a nitroglycerin-induced model of migraine in male mice.
Br J Pharmacol.
178:4626-4645
PMID: 34363208 -
Cserép et al.
(2020)
Microglia Monitor and Protect Neuronal Function Through Specialized Somatic Purinergic Junctions.
Science.
367:528
PMID: 31831638 -
Alice et al.
(2020)
Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells.
Cancers (Basel).
12
PMID: 31968611 -
Anne-Mette et al.
(2020)
Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis.
Int J Mol Sci.
21
PMID: 32781764 -
Uderhardt et al.
(2019)
Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.
Cell.
177:541
PMID: 30955887 -
Madry et al.
(2018)
Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1.
Neuron.
97:299
PMID: 29290552 -
Smith et al.
(2017)
Protease-activated receptor-4 and P2Y12 Dimerize, Co-Internalize and Activate Akt Signaling via Endosomal Recruitment of β-arrestin.
J Biol Chem.
2017;
PMID: 28652403 -
Abud et al.
(2017)
iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases.
Neuron.
94:278
PMID: 28426964 -
Takayama et al.
(2016)
Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system
Scientific Reports.
6:30006
PMID: 27445174 -
Aungraheeta et al.
(2016)
Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor.
Blood.
128:2717
PMID: 27694321 -
Nishimura et al.
(2015)
The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.
PLoS Pathog.
11:e1005184
PMID: 26430888 -
Wang et al.
(2014)
Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells.
PLoS One.
9:e110101
PMID: 25290311
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Customer Reviews for PSB 0739 (2)
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Species: MouseAssay Type: In VivoCell Line/Tissue: phagocyteH20; dilution 10 μM
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Species: MouseAssay Type: Ex VivoCell Line/Tissue: acute brain sliceUsed to block P2Y12 in acute brain slices. Monitored was the motility of microglia. No significant effect was found.
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