PSB 0739

Name: PSB 0739
Brand: Tocris Bioscience
SKU: 3983
Rating: 4 (2 reviews)

Catalog # 3983 | Tocris Bioscience a Bio-Techne Brand

(2)

Citations (15)

COA / SDS

Highly potent P2Y12 antagonist

Key Product Details

Description:	Highly potent P2Y₁₂ antagonist
Chemical Name:	1-Amino-9,10-dihydro-9,10-dioxo-4-[[4-(phenylamino)-3-sulfophenyl]amino]-2-anthracenesulfonic acid sodium salt
Purity:	≥95% (HPLC)
Molecular Weight:	609.54

View Full Technical Details for PSB 0739

Technical Data
Citations (15) / Reviews (2)

Biological Activity for PSB 0739

PSB 0739 is a highly potent P2Y₁₂ receptor antagonist (K_i = 24.9 nM). Unlike clopidogrel (Cat. No. 2490), does not require bioactivation.

Licensing Information

Sold with the permission of the University of Bonn.

Technical Data for PSB 0739

M. Wt	609.54
Formula	C₂₆H₁₇N₃Na₂O₈S₂
Storage	Desiccate at RT
Purity	≥95% (HPLC)
CAS Number	1052087-90-7
PubChem ID	44583582
InChi Key	QBLLYXXXOJUNCV-UHFFFAOYSA-L
Smiles	[Na+].[Na+].NC1=C(C=C(NC2=CC(=C(NC3=CC=CC=C3)C=C2)S([O-])(=O)=O)C2=C1C(=O)C1=CC=CC=C1C2=O)S([O-])(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PSB 0739

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	15.24	25

Preparing Stock Solutions for PSB 0739

The following data is based on the product molecular weight 609.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	6.56 mL	32.81 mL	65.62 mL
1.25 mM	1.31 mL	6.56 mL	13.12 mL
2.5 mM	0.66 mL	3.28 mL	6.56 mL
12.5 mM	0.13 mL	0.66 mL	1.31 mL

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References for PSB 0739

References are publications that support the biological activity of the product.

Felix Development of a comprehensive set of P2 receptor pharmacological research compounds. Purinerg.Sig. 2011 PMID: 22052555
Hoffmann Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y₁₂ receptor. J.Pharmacol.Exp.Ther. 2009 PMID: 19690189
Baqi High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y₁₂ receptors. J.Med.Chem. 2009 PMID: 19463000

Citations for PSB 0739 (15)

Showing 1 - 10 of 15 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for PSB 0739 include:

Domokos et al. (2022) Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions. J Exp Med. 219
PMID: 35201268
Tibor et al. (2022) The dualistic role of the purinergic P2Y12-receptor in an in vivo model of Parkinson's disease: Signalling pathway and novel therapeutic targets. Pharmacol Res. 176:106045
PMID: 34968684
Stefano L et al. (2022) TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia. Elife. 11
PMID: 35191835
Mária et al. (2021) Involvement of P2Y12 receptors in a nitroglycerin-induced model of migraine in male mice. Br J Pharmacol. 178:4626-4645
PMID: 34363208
Cserép et al. (2020) Microglia Monitor and Protect Neuronal Function Through Specialized Somatic Purinergic Junctions. Science. 367:528
PMID: 31831638
Alice et al. (2020) Antiplatelet Drug Ticagrelor Enhances Chemotherapeutic Efficacy by Targeting the Novel P2Y12-AKT Pathway in Pancreatic Cancer Cells. Cancers (Basel). 12
PMID: 31968611
Anne-Mette et al. (2020) Prevention of P2 Receptor-Dependent Thrombocyte Activation by Pore-Forming Bacterial Toxins Improves Outcome in A Murine Model of Urosepsis. Int J Mol Sci. 21
PMID: 32781764
Uderhardt et al. (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 177:541
PMID: 30955887
Madry et al. (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 97:299
PMID: 29290552
Smith et al. (2017) Protease-activated receptor-4 and P2Y12 Dimerize, Co-Internalize and Activate Akt Signaling via Endosomal Recruitment of β-arrestin. J Biol Chem. 2017;
PMID: 28652403
Abud et al. (2017) iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases. Neuron. 94:278
PMID: 28426964
Takayama et al. (2016) Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system Scientific Reports. 6:30006
PMID: 27445174
Aungraheeta et al. (2016) Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 128:2717
PMID: 27694321
Nishimura et al. (2015) The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 11:e1005184
PMID: 26430888
Wang et al. (2014) Nucleolin down-regulation is involved in ADP-induced cell cycle arrest in S phase and cell apoptosis in vascular endothelial cells. PLoS One. 9:e110101
PMID: 25290311

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Showing 1 - 10 of 15 citations Showing All

Customer Reviews for PSB 0739 (2)

4 out of 5

2 customer ratings

5 stars

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Good inhibitor

Name: Anonymous

Species: Mouse

Assay Type: In Vivo

Cell Line/Tissue: phagocyte

H20; dilution 10 μM

PMID: PMID: 30955887
P2Y12 blocker

Name: Anonymous

Species: Mouse

Assay Type: Ex Vivo

Cell Line/Tissue: acute brain slice

Used to block P2Y12 in acute brain slices. Monitored was the motility of microglia. No significant effect was found.

There are no reviews that match your criteria.