PROTAC®(H-PGDS)-7
Tocris Bioscience, part of Bio-Techne | Catalog # 8004
Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)
Key Product Details
Description
Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)
Product Description
PROTAC®(H-PGDS)-7 is a potent Degrader of hematopoietic prostaglandin D2 synthase (H-PGDS; DC50 = 17pM after 24 hours). Comprises the H-PGDS inhibitor TFC-007 (Cat. No. 5108) directly linked to E3 ligase cereblon. Suppresses prostaglandin D2 production in vitro and in vivo.
PROTAC®(H-PGDS)-8 negative control (Cat. No. 8005) also available.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Licensing Information
Sold under license from National Institute of Health Sciences, Japan and Tsuzuki Gakuen.Product Specifications
Molecular Weight
742.79
Formula
C40H38N8O7
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
CAS Number
2761281-50-7
PubChem ID
162679258
InChI Key
KQNXUQJGOJWQGL-UHFFFAOYSA-N
SMILES
O=C(C1=CN=C(OC2=CC=CC=C2)N=C1)NC3=CC=C(N4CCC(CC4)C(N5CCN(CC5)C(C=CC=C6C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)C=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 74.28 | 100 |
Preparing Stock Solutions
for PROTAC®(H-PGDS)-7
The following data is based on the product molecular weight 742.79
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.35 mL | 6.73 mL | 13.46 mL |
| 5 mM | 0.27 mL | 1.35 mL | 2.69 mL |
| 10 mM | 0.13 mL | 0.67 mL | 1.35 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.27 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Murakami Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D2 synthase. RSC Med.Chem. 2022 PMID: 36561070
- Yokoo Discovery of a highly potent and selective Degrader targeting hematopoietic prostaglandin D synthase via in silico design. J.Med.Chem. 2021 PMID: 34652145
- Osawa CRBN ligand expansion for hematopoietic prostaglandin D2 synthase (H-PGDS) targeting PROTAC design and their in vitro ADME profiles. Bioorg.Med.Chem. 2023 PMID: 37018877
Product Specific Notices for PROTAC®(H-PGDS)-7
For research use only
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