PROTAC^®(H-PGDS)-7

Name: PROTAC ® (H-PGDS)-7
Brand: Tocris Bioscience
SKU: 8004

Tocris Bioscience, part of Bio-Techne | Catalog # 8004

COA / SDS

Potent hematopoietic prostaglandin D2 synthase Degrader (PROTAC®)

Key Product Details

Description:	Potent hematopoietic prostaglandin D₂ synthase Degrader (PROTAC^®)
Chemical Name:	N-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-1-piperazinyl]carbonyl]-1-piperidinyl]phenyl]-2-phenoxy-5-pyrimidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	742.79

View Full Technical Details for PROTAC^®(H-PGDS)-7

Technical Data
Citations

Biological Activity for PROTAC^®(H-PGDS)-7

PROTAC^®(H-PGDS)-7 is a potent Degrader of hematopoietic prostaglandin D₂ synthase (H-PGDS; DC₅₀ = 17pM after 24 hours). Comprises the H-PGDS inhibitor TFC-007 (Cat. No. 5108) directly linked to E3 ligase cereblon. Suppresses prostaglandin D₂ production in vitro and in vivo.

PROTAC^®(H-PGDS)-8 negative control (Cat. No. 8005) also available.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from National Institute of Health Sciences, Japan and Tsuzuki Gakuen.

Technical Data for PROTAC^®(H-PGDS)-7

M. Wt	742.79
Formula	C₄₀H₃₈N₈O₇
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2761281-50-7
PubChem ID	162679258
InChi Key	KQNXUQJGOJWQGL-UHFFFAOYSA-N
Smiles	O=C(C1=CN=C(OC2=CC=CC=C2)N=C1)NC3=CC=C(N4CCC(CC4)C(N5CCN(CC5)C(C=CC=C6C(N7C8C(NC(CC8)=O)=O)=O)=C6C7=O)=O)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PROTAC^®(H-PGDS)-7

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	74.28	100

Preparing Stock Solutions for PROTAC^®(H-PGDS)-7

The following data is based on the product molecular weight 742.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.35 mL	6.73 mL	13.46 mL
5 mM	0.27 mL	1.35 mL	2.69 mL
10 mM	0.13 mL	0.67 mL	1.35 mL
50 mM	0.03 mL	0.13 mL	0.27 mL

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References for PROTAC^®(H-PGDS)-7

References are publications that support the biological activity of the product.

Murakami Structure-activity relationship study of PROTACs against hematopoietic prostaglandin D₂ synthase. RSC Med.Chem. 2022 PMID: 36561070
Yokoo Discovery of a highly potent and selective Degrader targeting hematopoietic prostaglandin D synthase via in silico design. J.Med.Chem. 2021 PMID: 34652145
Osawa CRBN ligand expansion for hematopoietic prostaglandin D₂ synthase (H-PGDS) targeting PROTAC design and their in vitro ADME profiles. Bioorg.Med.Chem. 2023 PMID: 37018877

PROTAC^®(H-PGDS)-7

Tocris Bioscience, part of Bio-Techne | Catalog # 8004

Key Product Details

Biological Activity for PROTAC^®(H-PGDS)-7

Licensing Information

Technical Data for PROTAC^®(H-PGDS)-7

Solubility for PROTAC^®(H-PGDS)-7

Preparing Stock Solutions for PROTAC^®(H-PGDS)-7

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PROTAC^®(H-PGDS)-7

Product Documents for PROTAC^®(H-PGDS)-7

COA

Certificate of Analysis

SDS

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PROTAC®(H-PGDS)-7

Tocris Bioscience, part of Bio-Techne | Catalog # 8004

Key Product Details

Biological Activity for PROTAC®(H-PGDS)-7

Licensing Information

Technical Data for PROTAC®(H-PGDS)-7

Solubility for PROTAC®(H-PGDS)-7

Preparing Stock Solutions for PROTAC®(H-PGDS)-7

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for PROTAC®(H-PGDS)-7

Product Documents for PROTAC®(H-PGDS)-7

COA

Certificate of Analysis

SDS

PROTAC^®(H-PGDS)-7

Biological Activity for PROTAC^®(H-PGDS)-7

Technical Data for PROTAC^®(H-PGDS)-7

Solubility for PROTAC^®(H-PGDS)-7

Preparing Stock Solutions for PROTAC^®(H-PGDS)-7

References for PROTAC^®(H-PGDS)-7

Product Documents for PROTAC^®(H-PGDS)-7