Prosaptide TX14(A)

Name: Prosaptide TX14(A)
Brand: Tocris Bioscience
SKU: 5151

Tocris Bioscience, part of Bio-Techne | Catalog # 5151

Citations (4)

COA / SDS

Potent GPR37 and GPR37L1 agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent GPR37 and GPR37L1 agonist

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Product Description

Prosaptide TX14(A) is a potent GPR37L1 and GPR37 agonist (EC₅₀ values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective.

Product Specifications

Molecular Weight

1579.72

Formula

C₆₉H₁₁₀N₁₆O₂₆

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

196391-82-9

PubChem ID

16197909

InChI Key

SMUKRAODILXPSW-SRWCCNGVSA-N

SMILES

[H]N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Meyer GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 2013 PMID: 23690594
Hiraiwa Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc.Natl.Acad.Sci.USA. 1997 PMID: 9114068