ProK
Tocris Bioscience, part of Bio-Techne | Catalog # 7361
Unnatural amino acid, propargyl lysine derivative
Key Product Details
Description
Unnatural amino acid, propargyl lysine derivative
Product Description
ProK is a lysine-based unnatural amino acid (UAA) used for genetic code expansion. It enables bioconjugation of fluorescent probes in E. coli or multicellular organisms.Product Specifications
Molecular Weight
264.71
Formula
C10H16N2O4.HCl
Storage
Store at -20°C
Purity
≥95%
Chemical Name
N6-[(2-Propyn-1-yloxy)carbonyl]-L-lysine hydrochloride
CAS Number
1428330-91-9
PubChem ID
118898827
InChI Key
ZYUXGVUWYHHZTD-QRPNPIFTSA-N
SMILES
C(NCCCC[C@@H](C(O)=O)N)(OCC#C)=O.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 26.47 | 100 | |
| DMSO | 26.47 | 100 |
Preparing Stock Solutions
for ProK
The following data is based on the product molecular weight 264.71
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.78 mL | 18.89 mL | 37.78 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.56 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Meineke Site-specific incorporation of two ncAAs for two-color bioorthogonal labeling and crosslinking of proteins on live mammalian cells. Cell Rep. 2020 PMID: 32579937
- Greiss Expanding the genetic code of an animal. J.Am.Chem.Soc. 2011 PMID: 21819153
- Neumann Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome. Nature 2010 PMID: 20154731
- Li Palladium-triggered deprotection chemistry for protein activation in living cells. Nat. Chem. 2014 PMID: 24651204
- Nguyen Genetic encoding and labeling of aliphatic azides and alkynes in recombinant proteins via a pyrrolysyl-tRNA Synthetase/tRNA(CUA) pair and click chemistry. J.Am.Chem.Soc. 2009 PMID: 19514718
Product Specific Notices for ProK
For research use only
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