Probucol

Name: Probucol
Brand: Tocris Bioscience
SKU: 2775

Tocris Bioscience, part of Bio-Techne | Catalog # 2775

Citations (158)

COA / SDS

ABCA1 (CERP) inhibitor; also antioxidant, anti-inflammatory and hypocholesterolemic agent

Discontinued Product

2775 has been discontinued. View all Additional Antioxidant Compounds products.

Key Product Details

Description:	ABCA1 (CERP) inhibitor; also antioxidant, anti-inflammatory and hypocholesterolemic agent
Chemical Name:	4,4'-[(1-Methylethylidene)bis(thio)]bis[2,6-bis(1,1-dimethylethyl)phenol]
Purity:	≥99% (HPLC)
Molecular Weight:	516.84

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Technical Data
Citations

Biological Activity for Probucol

Probucol is an ABCA1 (CERP) inhibitor. Inhibits cholesterol efflux from J774 macrophages expressing ABCA1 by up to 80%. Inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Antioxidant, anti-inflammatory and hypocholesterolemic agent.

Technical Data for Probucol

M. Wt	516.84
Formula	C₃₁H₄₈O₂S₂
Storage	Desiccate at +4°C
Purity	≥99% (HPLC)
CAS Number	23288-49-5
PubChem ID	4912
InChi Key	FYPMFJGVHOHGLL-UHFFFAOYSA-N
Smiles	CC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Probucol

References are publications that support the biological activity of the product.

Wu Probucol inactivates ABCA1 in the plasma membrane with respect to its mediation of apolipoprotein binding and high density lipoprotein assembly and to its proteolytic degradation. J.Biol.Chem. 2004 PMID: 15140889
Wu Probucol [4,4'-[(1-methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E-deficient mice. J.Pharmacol.Exp.Ther. 2007 PMID: 17293560
Favari Probucol inhibits ABCA1-mediated cellular lipid efflux. Arterioscler.Thromb.Vasc.Biol. 2004 PMID: 15514211
Ruixing Pretreatment with prob. attenuates cardiomyocyte apoptosis in a rabbit model of ischemia/reperfusion. Scand.J.Clin.Lab.Invest. 2006 PMID: 17101546

Probucol

Tocris Bioscience, part of Bio-Techne | Catalog # 2775

Key Product Details

Biological Activity for Probucol

Technical Data for Probucol

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Probucol

Product Documents for Probucol

COA

Certificate of Analysis

SDS

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