Pridopidine

Product Description

Pridopidine is a selective high affinity σ-1 receptor (S1R) agonist (Ki = 7.1 nM in both HEK293 cells and rat striatal membranes). Pridopidine displays ~30-fold and ~100-fold selectivity over the dopamine D₃ receptor and the D₂ receptor, respectively. Pridopidine is a low affinity dopamine D₂ receptor antagonist (Ki (low) = 17.5 μM; Ki (high) = 7.5 μM). Pridopidine upregulates gene expression induced by BDNF in rat striatum in vivo in an S1R-dependent manner. Pridopidine improves motor function and shows neuroprotective effects in Huntington's disease animal models. Pridopidine restores neuromuscular junction activity in amyotrophic lateral sclerosis models in vitro and in vivo. Orally bioavailable.

Solubility

Preparing Stock Solutions for Pridopidine

The following data is based on the product molecular weight 281.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.55 mL	17.77 mL	35.53 mL
5 mM	0.71 mL	3.55 mL	7.11 mL
10 mM	0.36 mL	1.78 mL	3.55 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ryskamp The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol.Dis. 2017 PMID: 27818324
• Sahlholm The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor. Mol.Psychiatry 2013 PMID: 22349783
• Geva Pridopidine activates neuroprotective pathways impaired in Huntington Disease. Hum.Mol.Genet. 2016 PMID: 27466197
• Ye Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases. J.Med.Chem. 2020 PMID: 33111525
• Ionescu Targeting the sigma-1 receptor via pridopidine ameliorates central features of ALS pathology in a SOD1^G93A model. Cell Death Dis. 2019 PMID: 30824685