Pridopidine

Name: Pridopidine
Brand: Tocris Bioscience
SKU: 7630

Tocris Bioscience, part of Bio-Techne | Catalog # 7630

Citations (3)

COA / SDS

Highly selective σ1 agonist

Key Product Details

Description:	Highly selective σ₁ agonist
Alternative Names:	PL-101,ACR16,Huntexil
Chemical Name:	4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine
Purity:	≥98% (HPLC)
Molecular Weight:	281.42

View Full Technical Details for Pridopidine

Technical Data
Citations

Biological Activity for Pridopidine

Pridopidine is a selective high affinity σ-1 receptor (S1R) agonist (Ki = 7.1 nM in both HEK293 cells and rat striatal membranes). Pridopidine displays ~30-fold and ~100-fold selectivity over the dopamine D₃ receptor and the D₂ receptor, respectively. Pridopidine is a low affinity dopamine D₂ receptor antagonist (Ki (low) = 17.5 μM; Ki (high) = 7.5 μM). Pridopidine upregulates gene expression induced by BDNF in rat striatum in vivo in an S1R-dependent manner. Pridopidine improves motor function and shows neuroprotective effects in Huntington's disease animal models. Pridopidine restores neuromuscular junction activity in amyotrophic lateral sclerosis models in vitro and in vivo. Orally bioavailable.

Compound Libraries for Pridopidine

Pridopidine is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Pridopidine

M. Wt	281.42
Formula	C₁₅H₂₃NO₂S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	346688-38-8
PubChem ID	9795739
InChi Key	YGKUEOZJFIXDGI-UHFFFAOYSA-N
Smiles	CS(C1=CC(C2CCN(CCC)CC2)=CC=C1)(=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pridopidine

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.14	100
	ethanol	28.14	100

Preparing Stock Solutions for Pridopidine

The following data is based on the product molecular weight 281.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.55 mL	17.77 mL	35.53 mL
5 mM	0.71 mL	3.55 mL	7.11 mL
10 mM	0.36 mL	1.78 mL	3.55 mL
50 mM	0.07 mL	0.36 mL	0.71 mL

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Reconstitution Calculator

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References for Pridopidine

References are publications that support the biological activity of the product.

Ryskamp The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol.Dis. 2017 PMID: 27818324
Sahlholm The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor. Mol.Psychiatry 2013 PMID: 22349783
Geva Pridopidine activates neuroprotective pathways impaired in Huntington Disease. Hum.Mol.Genet. 2016 PMID: 27466197
Ye Small molecules selectively targeting sigma-1 receptor for the treatment of neurological diseases. J.Med.Chem. 2020 PMID: 33111525
Ionescu Targeting the sigma-1 receptor via pridopidine ameliorates central features of ALS pathology in a SOD1^G93A model. Cell Death Dis. 2019 PMID: 30824685