Pomalidomide 4'-alkylC4-acid
Tocris Bioscience, part of Bio-Techne | Catalog # 7209
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
Key Product Details
Description
Cereblon ligand with alkyl linker and terminal acid for onward chemistry
Product Description
Pomalidomide 4'-alkylC4-acid is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines
This product is provided for use in onward chemistry. Suitable solvents can be used.Product Specifications
Molecular Weight
373.37
Formula
C18H19N3O6
Storage
Store at -20°C
Purity
≥95% (HPLC)
Chemical Name
5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentanoic acid
CAS Number
2225940-48-5
PubChem ID
139331580
InChI Key
JUPYDAIBDNUUIF-UHFFFAOYSA-N
SMILES
OC(CCCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMF | 37.34 | 100 | |
| DMSO | 37.34 | 100 |
Preparing Stock Solutions
for Pomalidomide 4'-alkylC4-acid
The following data is based on the product molecular weight 373.37
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.39 mL | 26.78 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Product Specific Notices for Pomalidomide 4'-alkylC4-acid
For research use only
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