Pomalidomide 4'-alkylC4-acid

Name: Pomalidomide 4'-alkylC4-acid
Brand: Tocris Bioscience
SKU: 7209

Tocris Bioscience, part of Bio-Techne | Catalog # 7209

COA / SDS

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Key Product Details

Description:	Cereblon ligand with alkyl linker and terminal acid for onward chemistry
Chemical Name:	5-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]pentanoic acid
Purity:	≥95% (HPLC)
Molecular Weight:	373.37

View Full Technical Details for Pomalidomide 4'-alkylC4-acid

Technical Data
Citations

Biological Activity for Pomalidomide 4'-alkylC4-acid

Pomalidomide 4'-alkylC4-acid is a functionalized cereblon ligand for PROTAC^® research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Pomalidomide 4'-alkylC4-acid

M. Wt	373.37
Formula	C₁₈H₁₉N₃O₆
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2225940-48-5
PubChem ID	139331580
InChi Key	JUPYDAIBDNUUIF-UHFFFAOYSA-N
Smiles	OC(CCCCNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pomalidomide 4'-alkylC4-acid

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	37.34	100
	DMF	37.34	100

Preparing Stock Solutions for Pomalidomide 4'-alkylC4-acid

The following data is based on the product molecular weight 373.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

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Reconstitution Calculator

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Product Documents for Pomalidomide 4'-alkylC4-acid

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.