PNU 74654
Tocris Bioscience, part of Bio-Techne | Catalog # 3534
β-catenin binder; inhibits Wnt signaling
Key Product Details
Description
β-catenin binder; inhibits Wnt signaling
Product Description
Binds to β-catenin (KD = 450 nM). Inhibits the interaction between β-catenin and T cell factor 4 (Tcf4) and disrupts the Wnt signaling pathway. Promotes neural differentiation of hPSCs as part of a chemical cocktail.Product Specifications
Molecular Weight
320.34
Formula
C19H16N2O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
CAS Number
113906-27-7
PubChem ID
9836739
InChI Key
JJEDWBQZCRESJL-DEDYPNTBSA-N
SMILES
O=C(N/N=C/C2=CC=C(C)O2)C1=C(OC3=CC=CC=C3)C=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.03 | 100 |
Preparing Stock Solutions
for PNU 74654
The following data is based on the product molecular weight 320.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.22 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wells and McClendon Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. Nature 2007 PMID: 18075579
- Chen Chemically defined neural conversion of human pluripotent stem cells. Methods Mol.Biol. 2019 PMID: 30656621
- Trosset Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins 2006 PMID: 16568448
Product Specific Notices for PNU 74654
For research use only
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