PNU 142633

Name: PNU 142633
Brand: Tocris Bioscience
SKU: 1985

Tocris Bioscience, part of Bio-Techne | Catalog # 1985

Citations (39)

COA / SDS

Highly selective 5-HT1D agonist

Key Product Details

Description:	Highly selective 5-HT_1D agonist
Chemical Name:	(1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	422.53

View Full Technical Details for PNU 142633

Technical Data
Citations

Biological Activity for PNU 142633

PNU 142633 is a very selective, high affinity 5-HT_1D receptor agonist (K_i values are 6 and > 18000 nM at human 5-HT_1D and 5-HT_1B receptors respectively). Inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo.

Compound Libraries for PNU 142633

PNU 142633 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for PNU 142633

M. Wt	422.53
Formula	C₂₄H₃₀N₄O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	187665-65-2
PubChem ID	9845148
InChi Key	PNTVCCRNJOGKGA-QFIPXVFZSA-N
Smiles	O=C(NC)C3=CC(CCO2)=C(C=C3)[C@@H]2CCN1CCN(C4=CC=C(C(N)=O)C=C4)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PNU 142633

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	42.25	100

Preparing Stock Solutions for PNU 142633

The following data is based on the product molecular weight 422.53.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.37 mL	11.83 mL	23.67 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
10 mM	0.24 mL	1.18 mL	2.37 mL
50 mM	0.05 mL	0.24 mL	0.47 mL

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References for PNU 142633

References are publications that support the biological activity of the product.

Sanchez-Lopez Pharmacological profile of the 5-HT-induced inhibition of cardioaccelerator sympathetic outflow in pithed rats: correlation with 5-HT₁ and putative 5-ht_5A/5B receptors. Br.J.Pharmacol. 2003 PMID: 14504136
Roon Bovine isolated middle cerebral artery contractions to antimigraine drugs. Naunyn-Schmied.Arch.Pharmacol.
McCall Preclinical studies characterizing the anti-migraine and cardiovascular effects of the selective 5-HT_1D receptor agonist PNU-142633. Cephalalgia 2002 PMID: 12485205