(+)-SK&F 10047 hydrochloride

Name: (+)-SK&F 10047 hydrochloride
Brand: Tocris Bioscience
SKU: 1079

Tocris Bioscience, part of Bio-Techne | Catalog # 1079

Citations (6)

COA / SDS

σ1 selective agonist

Key Product Details

Description:	σ₁ selective agonist
Chemical Name:	(2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	293.84

View Full Technical Details for (+)-SK&F 10047 hydrochloride

Technical Data
Citations

Biological Activity for (+)-SK&F 10047 hydrochloride

(+)-SK&F 10047 hydrochloride is a prototypical σ₁ receptor agonist. Behaviorally active in animal models of memory and stress.

Technical Data for (+)-SK&F 10047 hydrochloride

M. Wt	293.84
Formula	C₁₇H₂₃NO.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	133005-41-1
PubChem ID	16759596
InChi Key	ZTGMHFIGNYXMJV-XSCGHNKWSA-N
Smiles	Cl.C[C@@H]1[C@@H]2CC3=CC=C(O)C=C3[C@@]1(C)CCN2CC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-SK&F 10047 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.38	100
	DMSO	29.38	100

Preparing Stock Solutions for (+)-SK&F 10047 hydrochloride

The following data is based on the product molecular weight 293.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	17.02 mL	34.03 mL
5 mM	0.68 mL	3.40 mL	6.81 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for (+)-SK&F 10047 hydrochloride

References are publications that support the biological activity of the product.

Matsuno Involvement of σ₁ receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 1995 PMID: 8535837
Walker Sigma receptors: biology and function. Pharmacol.Rev. 1990 PMID: 1964225
Kamei (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ₁ sites. Eur.J.Pharmacol. 1996 PMID: 8874133