(+)-SK&F 10047 hydrochloride

Name: (+)-SK&F 10047 hydrochloride
Brand: Tocris Bioscience
SKU: 1079

Tocris Bioscience a Bio-Techne Brand

Catalog # 1079

Citations (5)

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Key Product Details

Description:	σ₁ selective agonist
Chemical Name:	(2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	293.84

View Full Technical Details for (+)-SK&F 10047 hydrochloride

Biological Activity for (+)-SK&F 10047 hydrochloride

(+)-SK&F 10047 hydrochloride is a prototypical σ₁ receptor agonist. Behaviorally active in animal models of memory and stress.

Technical Data for (+)-SK&F 10047 hydrochloride

M. Wt	293.84
Formula	C₁₇H₂₃NO.HCl
Storage	Desiccate at +4°C
Purity	≥98% (HPLC)
CAS Number	133005-41-1
PubChem ID	16759596
InChi Key	ZTGMHFIGNYXMJV-XSCGHNKWSA-N
Smiles	Cl.C[C@@H]1[C@@H]2CC3=CC=C(O)C=C3[C@@]1(C)CCN2CC=C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-SK&F 10047 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	29.38	100
	DMSO	29.38	100

Preparing Stock Solutions for (+)-SK&F 10047 hydrochloride

The following data is based on the product molecular weight 293.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.40 mL	17.02 mL	34.03 mL
5 mM	0.68 mL	3.40 mL	6.81 mL
10 mM	0.34 mL	1.70 mL	3.40 mL
50 mM	0.07 mL	0.34 mL	0.68 mL

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References for (+)-SK&F 10047 hydrochloride

References are publications that support the biological activity of the product.

Kamei (+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ₁ sites. Eur.J.Pharmacol. 1996 PMID: 8874133
Matsuno Involvement of σ₁ receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res. 1995 PMID: 8535837
Walker Sigma receptors: biology and function. Pharmacol.Rev. 1990 PMID: 1964225

Citations for (+)-SK&F 10047 hydrochloride (5)

Showing 1 - 5 of 5 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for (+)-SK&F 10047 hydrochloride include:

Brailoiu et al. (2019) Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca²⁺ Signals through Sigma-1 Receptors. Cell Rep. 26:330
PMID: 30625315
Kasaharaa et al. (2016) The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes Neuroscience. 340:176
PMID: 27815022
Rodríguez-Muñoz et al. (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Int J Neuropsychopharmacol. 6:35458
PMID: 26461475
Sánchez-Blázquez et al. (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. PLoS One. 17:1943
PMID: 24485144
Amer et al. (2013) Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands. Br J Pharmacol. 168:1445
PMID: 23121507

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