(+)-Clopidogrel hydrogen sulfate

Name: (+)-Clopidogrel hydrogen sulfate
Brand: Tocris Bioscience
SKU: 1820

Tocris Bioscience, part of Bio-Techne | Catalog # 1820

Citations (12)

COA / SDS

Selective P2Y12 antagonist

Key Product Details

Description:	Selective P2Y₁₂ antagonist
Alternative Names:	Plavix
Chemical Name:	(S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogen sulfate
Purity:	≥98% (HPLC)
Molecular Weight:	419.9

View Full Technical Details for (+)-Clopidogrel hydrogen sulfate

Technical Data
Citations

Biological Activity for (+)-Clopidogrel hydrogen sulfate

(+)-Clopidogrel hydrogen sulfate is a selective, high affinity P2Y₁₂ receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity. Active enantiomer of (±)-clopidogrel hydrochloride (Cat. No. 2490). Requires bioactivation.

Technical Data for (+)-Clopidogrel hydrogen sulfate

M. Wt	419.9
Formula	C₁₆H₁₆ClNO₂S.H₂SO₄
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	120202-66-6
PubChem ID	115366
InChi Key	FDEODCTUSIWGLK-RSAXXLAASA-N
Smiles	OS(O)(=O)=O.COC(=O)[C@@H](N1CCC2=C(C1)C=CS2)C1=CC=CC=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for (+)-Clopidogrel hydrogen sulfate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	41.99	100
	DMSO	41.99	100

Preparing Stock Solutions for (+)-Clopidogrel hydrogen sulfate

The following data is based on the product molecular weight 419.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.91 mL	23.82 mL
5 mM	0.48 mL	2.38 mL	4.76 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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References for (+)-Clopidogrel hydrogen sulfate

References are publications that support the biological activity of the product.

Savi and Herbert Clopidogrel and ticlopidine: P2Y₁₂ adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis. Semin.Thromb.Haemostas.
Reist Very low chiral inversion of clopid. in rats: a pharmacokinetic and mechanistic investigation. Drug Metab.Disp.
Savi P2Y12, a new platelet ADP receptor, target of clopid. Biochem.Biophys.Res.Comm.
Kugelgen Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol.Ther. 2006 PMID: 16257449