PLpro inhibitor 6
Tocris Bioscience, part of Bio-Techne | Catalog # 7357
SARS-CoV and SARS-CoV-2 PLpro inhibitor
Key Product Details
Description
SARS-CoV and SARS-CoV-2 PLpro inhibitor
Product Description
PLpro inhibitor 6 is a SARS-CoV and SAR-CoV-2 PLpro inhibitor (IC50 values are 2.6 and 5.0 μM, respectively). Inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 μM, respectively).Product Specifications
Molecular Weight
346.43
Formula
C22H22N2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide
CAS Number
1093070-14-4
PubChem ID
44235889
InChI Key
KGPYBLOBHQLIET-OAHLLOKOSA-N
SMILES
C[C@H](C1=CC=CC2=C1C=CC=C2)NC(C3=C(C=CC(NC(C)=O)=C3)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.64 | 100 | |
| Ethanol | 6.93 | 20 |
Preparing Stock Solutions
for PLpro inhibitor 6
The following data is based on the product molecular weight 346.43
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.89 mL | 14.43 mL | 28.87 mL |
| 5 mM | 0.58 mL | 2.89 mL | 5.77 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.89 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ratia A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 18852458
- Freitas Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. ACS Infect.Dis. 2020 PMID: 32428392
Product Specific Notices for PLpro inhibitor 6
For research use only
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