PLpro inhibitor 19
Tocris Bioscience, part of Bio-Techne | Catalog # 7505
SARS-CoV-2 PLpro and replication inhibitor
Key Product Details
Description
SARS-CoV-2 PLpro and replication inhibitor
Product Description
PLpro inhibitor 19 is a SARS-CoV-2 inhibitor that inhibits viral replication and PLpro enzymatic activity in vitro (IC50 values are 0.18 μM and 0.44 μM respectively). PLpro inhibitor 19 is selective for PLpro over human deubiquitinating enzymes (DUBs) and DUB-like proteases and displays no cytotoxicity at up to 10 μM.Product Specifications
Molecular Weight
531.68
Formula
C31H38FN5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(R)-N-(3-Fluoro-5-((1-(1-(naphthalen-1-yl)ethyl)piperidine-4-carboxamido)methyl)phenyl)-4-methylpiperazine-1-carboxamide
CAS Number
2863607-73-0
PubChem ID
155925847
InChI Key
ZGUISYSWQQIAHK-JOCHJYFZSA-N
SMILES
CN1CCN(CC1)C(NC2=CC(F)=CC(CNC(C3CCN(CC3)[C@@H](C4=C5C=CC=CC5=CC=C4)C)=O)=C2)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.17 | 100 | |
| Ethanol | 53.17 | 100 |
Preparing Stock Solutions
for PLpro inhibitor 19
The following data is based on the product molecular weight 531.68
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.88 mL | 9.40 mL | 18.81 mL |
| 5 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 10 mM | 0.19 mL | 0.94 mL | 1.88 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Shan Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem.Biol. 2021 PMID: 33979649
Product Specific Notices for PLpro inhibitor 19
For research use only
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