PKI 14-22 amide, myristoylated is a cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (K_i = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Product Specifications

Molecular Weight

1209.50

Formula

C₅₃H₁₀₀N₂₀O₁₂

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

201422-03-9

PubChem ID

71312213

InChI Key

GQPQKQWUUHDDIS-JDLJUXOTSA-N

SMILES

[H]N(CC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O)C(=O)CCCCCCCCCCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in DMSO

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Background References

References are publications that support the biological activity of the product.

Zheng Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 2000 PMID: 10829013
Farrow Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 2003 PMID: 12947318
Glass Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 1989 PMID: 2722799

PKI 14-22 amide, myristoylated

Tocris Bioscience, part of Bio-Techne | Catalog # 2546

Key Product Details

Description

Alternative Names

View all Protein Kinase A Inhibitors »

Product Description