Pitavastatin calcium
Tocris Bioscience, part of Bio-Techne | Catalog # 4942
HMG-CoA reductase inhibitor
Key Product Details
Description
HMG-CoA reductase inhibitor
Alternative Names
NK-104
Product Description
Pitavastatin calcium is a synthetic inhibitor of HMG-CoA reductase (Ki = 1.7 nM). Lowers low-density lipoprotein (LDL) cholesterol levels. Displays minimal metabolism by cytochrome P450 enzymes, with little involvement of CYP3A4. Shown to improve cardiac function and survival in a rat model of hypertensive heart failure.Product Specifications
Molecular Weight
440.50
Formula
C25H23FNO4.0.5Ca
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
(3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt
CAS Number
147526-32-7
PubChem ID
5282451
InChI Key
RHGYHLPFVJEAOC-FFNUKLMVSA-L
SMILES
[Ca++].O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O.O[C@H](C[C@H](O)\C=C\C1=C(C2=CC=C(F)C=C2)C2=CC=CC=C2N=C1C1CC1)CC([O-])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.05 | 100 |
Preparing Stock Solutions
for Pitavastatin calcium
The following data is based on the product molecular weight 440.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.27 mL | 11.35 mL | 22.70 mL |
| 5 mM | 0.45 mL | 2.27 mL | 4.54 mL |
| 10 mM | 0.23 mL | 1.14 mL | 2.27 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.45 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Mukhtar Pitavastatin. Int.J.Clin.Pract. 2005 PMID: 15854203
- Aoki Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung. 1997 PMID: 9296275
- Saka Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J.Cardiovasc.Pharmacol. 2006 PMID: 16810078
Product Specific Notices for Pitavastatin calcium
For research use only
Loading...
Loading...