Pimozide

Name: Pimozide
Brand: tocris
SKU: 0937

Catalog # 0937

Datasheet / COA / SDS

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Key Product Details

Description:	D₂-like antagonist; also high affinity 5-HT₇ antagonist
Chemical Name:	1-[1-[4,4-Bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one
Purity:	≥99% (HPLC)
Molecular Weight:	461.55

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Biological Activity

Dopamine D₂-receptor antagonist and antipsychotic which binds with very high affinity to the cloned rat 5-HT₇ receptor (K_i = 0.5 nM).

Compound Libraries

Pimozide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	461.55
Formula	C₂₈H₂₉F₂N₃O
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	2062-78-4
PubChem ID	16362
InChi Key	YVUQSNJEYSNKRX-UHFFFAOYSA-N
Smiles	FC1=CC=C(C=C1)C(CCCN1CCC(CC1)N1C(=O)NC2=CC=CC=C12)C1=CC=C(F)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.23	20

Preparing Stock Solutions

The following data is based on the product molecular weight 461.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.83 mL	54.17 mL	108.33 mL
1 mM	2.17 mL	10.83 mL	21.67 mL
2 mM	1.08 mL	5.42 mL	10.83 mL
10 mM	0.22 mL	1.08 mL	2.17 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Roth Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J.Pharmacol.Exp.Ther. 1994 PMID: 7908055
Merck Index

Citations

Currently there are no citations for Pimozide.

Product Datasheets

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Pimozide, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov

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