Pilocarpine hydrochloride

Name: Pilocarpine hydrochloride
Brand: Tocris Bioscience
SKU: 0694
Price: 100 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 0694

Citations (3)

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Key Product Details

Description:	Muscarinic agonist
Chemical Name:	(3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	244.72

View Full Technical Details for Pilocarpine hydrochloride

Biological Activity for Pilocarpine hydrochloride

Pilocarpine hydrochloride is an M3 muscarinic acetycholine receptor agonist.

Compound Libraries for Pilocarpine hydrochloride

Pilocarpine hydrochloride is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Pilocarpine hydrochloride

M. Wt	244.72
Formula	C₁₁H₁₆N₂O₂.HCl
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	54-71-7
PubChem ID	5909
InChi Key	RNAICSBVACLLGM-GNAZCLTHSA-N
Smiles	O=C1[C@@]([H])(CC)[C@](CC2=CN=CN2C)([H])CO1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Pilocarpine hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	18.35	75
	water	24.47	100

Preparing Stock Solutions for Pilocarpine hydrochloride

The following data is based on the product molecular weight 244.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.09 mL	20.43 mL	40.86 mL
5 mM	0.82 mL	4.09 mL	8.17 mL
10 mM	0.41 mL	2.04 mL	4.09 mL
50 mM	0.08 mL	0.41 mL	0.82 mL

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References for Pilocarpine hydrochloride

References are publications that support the biological activity of the product.

Wang PilC modulates the cellular electrical properties of mammalian hearts by activating a cardiac M₃ receptor and a K⁺ current. Br.J.Pharmacol. 1999 PMID: 10372814
ten Berge Differences in the prejunctional effects of methach. and PilC on the release of endogenous acetylcholine from guinea-pig trachea. Naunyn Schmiedebergs Arch.Pharmacol. 1996 PMID: 8938659
Brown and Taylor Muscarinic receptor agonists and antagonists. The Pharmacological Basis of Therapeutics. Eds Goo

Citations for Pilocarpine hydrochloride (3)

Showing 1 - 3 of 3 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Pilocarpine hydrochloride include:

Overby et al. (2014) The structure of the trabecular meshwork, its connections to the ciliary muscle, and the effect of PilC on outflow facility in mice. Nat Chem Biol. 55:3727
PMID: 24833737
Deng et al. (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods. 68:323
PMID: 23933114
Tallarida et al. (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids. 42:2521
PMID: 21850438

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Product Documents for Pilocarpine hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.