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Picrotoxin

Tocris Bioscience a Bio-Techne Brand

GABA-A Receptor Antagonists Small Molecule
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1128/1G
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Key Product Details

Description: GABAA antagonist
Purity: ≥97% (HPLC)
Molecular Weight: 602.59

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Citations for Picrotoxin (125)

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Customer Reviews for Picrotoxin (4)

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  • Works as GABA-A receptor antagonist.
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Picrotoxin stock was prepared in DMSO and diluted with ACSF to 25 micromolar concentration. Bath application of Picrotoxin blocked evoked inhibitory postsynaptic currents in an ex-vivo slice preparation.
  • Picrotoxin blocks single-channel openings of GABA-A receptor
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    20 microM Picrotoxin concentration was used to block GABA-A receptor openings in nucleated cell membrane patches. Full block was achieved in ~30 seconds after application. Picture: GABA-A receptor openings under control conditions (top three traces) and after application of Picrotoxin (bottom trace).
    Picrotoxin Serum 1128
  • silence GABA activity
    Name: Karthik krishnamurthy
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: cortical neurons
    Used to block GABA activity in 16 day old cortical neurons. Effective at 10 micromolar concentration. Incubated for 30 minutes before measuring bursts.
    Picrotoxin Serum 1128
  • GABA blocker
    Name: Anonymous
    Species: Rat
    Assay Type: Ex Vivo
    Used for electrophysiology to block GABA currents. Works as expected

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Product Documents for Picrotoxin

Certificate of Analysis

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