Picrotoxin
Tocris Bioscience, part of Bio-Techne | Catalog # 1128
GABAA antagonist
Product Description
Picrotoxin is a GABAA receptor antagonist; potent CNS stimulant.Product Specifications
Molecular Weight
602.59
Formula
C30H34O13
Storage
Store at RT
Purity
≥97% (HPLC)
CAS Number
124-87-8
PubChem ID
6473767
InChI Key
VJKUPQSHOVKBCO-ZYMHLGHZSA-N
SMILES
[H][C@@]12OC([C@@](C1(C(C)=C)[H])([C@@]3(C[C@H]4O[C@]45C(O[C@]2([C@]35C)[H])=O)O)[H])=O.[H][C@@]67OC([C@@](C6(C(C)(O)C)[H])([C@@]8(C[C@H]9O[C@]9%10C(O[C@]7([C@]8%10C)[H])=O)O)[H])=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.05 | 20 | |
| Ethanol | 30.13 | 50 with gentle warming |
Preparing Stock Solutions
for Picrotoxin
The following data is based on the product molecular weight 602.59
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.32 mL | 16.60 mL | 33.19 mL |
| 2.5 mM | 0.66 mL | 3.32 mL | 6.64 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 25 mM | 0.07 mL | 0.33 mL | 0.66 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ette Picrotoxin blockade of inverterbrate glutamate-gated chloride channels: subunit dependence and evidence for binding within the pore. J.Neurochem. 1999 PMID: 9886084
- Newland and Cull-Candy On the mechanism of action of picrotoxin on GABA receptor channels in dissociated sympathetic neurones of the rat. J.Physiol. 1992 PMID: 1317428
- Dillon Enhancement by GABA of the association rate of picrotoxin and tert-butylbicyclophosphorothionate to the rat cloned α1β2γ2 GABAA receptor subtype. Br.J.Pharmacol. 1995 PMID: 7582470
Product Specific Notices for Picrotoxin
For research use only
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