Physostigmine hemisulfate

Name: Physostigmine hemisulfate
Brand: Tocris Bioscience
SKU: 0622

Catalog # 0622

Citations (6)

COA / SDS

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Key Product Details

Description:	Cholinesterase inhibitor
Chemical Name:	(3aS)-cis-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol methylcarbamate hemisulfate
Purity:	≥98% (HPLC)
Molecular Weight:	324.39

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Biological Activity

Physostigmine hemisulfate is a cholinesterase inhibitor.

Technical Data

M. Wt	324.39
Formula	C₁₅H₂₁N₃O₂.½H₂SO₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	64-47-1
PubChem ID	21872909
InChi Key	YYBNDIVPHIWTPK-UHFFFAOYSA-N
Smiles	OS(O)(=O)=O.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1.CNC(=O)OC1=CC=C2N(C)C3N(C)CCC3(C)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	32.44	100

Preparing Stock Solutions

The following data is based on the product molecular weight 324.39.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.08 mL	15.41 mL	30.83 mL
5 mM	0.62 mL	3.08 mL	6.17 mL
10 mM	0.31 mL	1.54 mL	3.08 mL
50 mM	0.06 mL	0.31 mL	0.62 mL

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References

References are publications that support the biological activity of the product.

Millard and Broomfield Anticholinesterases: medical applications of neurochemical principles. J.Neurochem 1995 PMID: 7722478

Citations for Physostigmine hemisulfate (6)

Showing 1 - 6 of 6 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for Physostigmine hemisulfate include:

Lecrux et al. (2017) Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. J Neurosci. 37:1518
PMID: 28069927
Parent et al. (2015) Cholinergic and ghrelinergic receptors and KCNQ channels in the medial PFC regulate the expression of palatability. Proc Natl Acad Sci U S A. 9:284
PMID: 26578914
Shin et al. (2015) Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens. Front Neurosci. 112:8124
PMID: 26080439
Galow et al. (2014) Energy substrates that fuel fast neuronal network oscillations. J Neurosci. 8:398
PMID: 25538552
Huchzermeyer et al. (2013) Oxygen consumption rates during three different neuronal activity states in the hippocampal CA3 network. J Cereb Blood Flow Metab. 33:263
PMID: 23168532
Chiu and Castillo (2008) Input-specific plasticity at excitatory synapses mediated by endocannabinoids in the dentate gyrus. Neuropharmacology. 54:68
PMID: 17706254

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