Phortress
Tocris Bioscience, part of Bio-Techne | Catalog # 4995
Prodrug of the antitumor agent 5F 203
Key Product Details
Description
Prodrug of the antitumor agent 5F 203
Product Description
Phortress is a prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Induces expression of CYP1A1 and generates adducts in the DNA of sensitive MCF7 and IGROV-1 cells.Product Specifications
Molecular Weight
459.41
Formula
C20H23FN4OS.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-2,6-Diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]hexanamide dihydrochloride
CAS Number
328087-38-3
PubChem ID
9804228
InChI Key
QZSMNTOCJVVFEU-CKUXDGONSA-N
SMILES
FC1=CC=C2C(N=C(C3=CC=C(NC([C@H](CCCCN)N)=O)C(C)=C3)S2)=C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 100 |
Preparing Stock Solutions
for Phortress
The following data is based on the product molecular weight 459.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.18 mL | 10.88 mL | 21.77 mL |
| 5 mM | 0.44 mL | 2.18 mL | 4.35 mL |
| 10 mM | 0.22 mL | 1.09 mL | 2.18 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bradshaw and Westwell The development of the antitumour benzothiazole prodrug, phortress, as a clinical candidate. Curr.Med.Chem. 2004 PMID: 15078163
- Leong In vitro, in vivo and in silico analyses of the antitumor activity of 2(-4-amino-3-methylphenyl)-5-fluorobenzothiazoles. Mol.Cancer Ther. 2004 PMID: 15634650
- Trapani DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated by aryl hydrocarbon receptor deficient MCF-7 cells. Br.J.Cancer 2003 PMID: 12592376
- Leong Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo. Br.J.Cancer 2003 PMID: 12569393
Product Specific Notices for Phortress
For research use only
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