Phenyl-glutarimide 4'-piperazine

Tocris Bioscience, part of Bio-Techne | Catalog # 7729

Piperazine-functionalized cereblon ligand for PROTAC development
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Key Product Details

Description

Piperazine-functionalized cereblon ligand for PROTAC development

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Product Description

Phenyl-glutarimide 4'-piperazine is a piperazine-functionalized cereblon ligand that can be used for PROTAC® Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications

Molecular Weight

346.25

Formula

C15H19N3O2.2HCl

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

3-[4-(1-Piperazinyl)phenyl]-2,6-piperidinedione dihydrochloride

CAS Number

2902651-89-0

InChI Key

DUZCAOXBUQOLHN-UHFFFAOYSA-N

SMILES

O=C1CCC(C2=CC=C(N3CCNCC3)C=C2)C(N1)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

Product Documents for Phenyl-glutarimide 4'-piperazine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Phenyl-glutarimide 4'-piperazine

For research use only

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