Phenyl-glutarimide 4'-piperazine

Name: Phenyl-glutarimide 4'-piperazine
Brand: Tocris Bioscience
SKU: 7729

Tocris Bioscience, part of Bio-Techne | Catalog # 7729

COA / SDS

Piperazine-functionalized cereblon ligand for PROTAC development

Key Product Details

Description:	Piperazine-functionalized cereblon ligand for PROTAC development
Chemical Name:	3-[4-(1-Piperazinyl)phenyl]-2,6-piperidinedione dihydrochloride
Purity:	≥95% (HPLC)
Molecular Weight:	346.25

View Full Technical Details for Phenyl-glutarimide 4'-piperazine

Technical Data
Citations

Biological Activity for Phenyl-glutarimide 4'-piperazine

Phenyl-glutarimide 4'-piperazine is a piperazine-functionalized cereblon ligand that can be used for PROTAC^® Degrader development. The compound can be used to develop PG-PROTACs that exhibit improved stability to hydrolysis and potency compared with PROTACs synthesized using IMiD (immunomodulatory imide drug) analogs.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Technical Data for Phenyl-glutarimide 4'-piperazine

M. Wt	346.25
Formula	C₁₅H₁₉N₃O₂.2HCl
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2902651-89-0
InChi Key	DUZCAOXBUQOLHN-UHFFFAOYSA-N
Smiles	O=C1CCC(C2=CC=C(N3CCNCC3)C=C2)C(N1)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Phenyl-glutarimide 4'-piperazine

References are publications that support the biological activity of the product.

Alcock Development of potent and selective Janus kinase 2/3 directing PG-PROTACs. ACS.Med.Chem.Lett. 2022 PMID: 35300081
Min Phenyl-glutarimides: alternative cereblon binders for the design of PROTACs. Angew.Chem.Int.Ed. 2021 PMID: 34614283