PHA 568487
Tocris Bioscience, part of Bio-Techne | Catalog # 3134
Selective α7 nAChR agonist
Key Product Details
Description
Selective α7 nAChR agonist
Product Description
PHA 568487 is an agonist of the α7 nicotinic acetylcholine receptor (Ki values are 44 and 2800 for α7 and 5-HT3 respectively, IC50 values are > 100 μM for α3β4 and α1β1δγ respectively, and % inhibition is < 1 and 5% for α4β2 and hERG respectively). Orally active and brain penetrant.Product Specifications
Molecular Weight
404.41
Formula
C16H20N2O3.C4H4O4
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-(3R)-1-Azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-1,4-benzodioxin-6-carboxamide fumarate
CAS Number
527680-57-5
PubChem ID
56972212
InChI Key
QYQZUGYJVHHHEE-QDSMGTAFSA-N
SMILES
O=C(C3=CC=C(OCCO4)C4=C3)N[C@@H]1C2CCN(CC2)C1.O=C(/C=C/C(O)=O)O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 40.44 | 100 | |
| DMSO | 40.44 | 100 |
Preparing Stock Solutions
for PHA 568487
The following data is based on the product molecular weight 404.41
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.47 mL | 12.36 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.47 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Walker Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists. Bioorg.Med.Chem. 2006 PMID: 17011782
Product Specific Notices for PHA 568487
For research use only
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