PH 797804
Tocris Bioscience, part of Bio-Techne | Catalog # 5866
Potent and selective p38α/β inhibitor
Product Description
PH 797804 is a potent and selective p38α/β inhibitor (IC50 values are 26 and 102 nM, respectively). Exhibits >100-fold selectivity for p38α/β over 71 other kinases, enzymes and GPCRs, including p38γ, p38δ, JNK and ERK2. Inhibits LPS-induced TNFα production in U937 monocytes in vitro. Suppresses acute and chronic inflammatory responses in rat models of arthritis. Orally active.PH 797804 is the (-)-atropisomer, which is 100-fold more potent than its (+)-atropisomer.
Licensing Information
Sold for research purposes under agreement from Pfizer IncProduct Specifications
Molecular Weight
477.30
Formula
C22H19BrF2N2O3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(-)-3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxo-1(2H)-pyridinyl]-N,4-dimethylbenzamide
CAS Number
1358027-80-1
PubChem ID
22049997
InChI Key
KCAJXIDMCNPGHZ-UHFFFAOYSA-N
SMILES
FC1=CC=C(COC2=C(Br)C(N(C3=CC(C(NC)=O)=CC=C3C)C(C)=C2)=O)C(F)=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.86 | 50 |
Preparing Stock Solutions
for PH 797804
The following data is based on the product molecular weight 477.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.19 mL | 20.95 mL | 41.90 mL |
| 2.5 mM | 0.84 mL | 4.19 mL | 8.38 mL |
| 5 mM | 0.42 mL | 2.10 mL | 4.19 mL |
| 25 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Selness Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. Bioorg.Med.Chem.Lett. 2011 PMID: 21641211
- Hope Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J.Pharmacol.Exp.Ther. 2009 PMID: 19720877
Product Specific Notices for PH 797804
For research use only
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