PFK 15

Name: PFK 15
Brand: Tocris Bioscience
SKU: 5339

Tocris Bioscience, part of Bio-Techne | Catalog # 5339

Citations (7)

COA / SDS

Selective PFKFB3 inhibitor

Key Product Details

Description:	Selective PFKFB3 inhibitor
Chemical Name:	1-(4-Pyridinyl)-3-(2-quinolinyl)-2-propen-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	260.29

View Full Technical Details for PFK 15

Technical Data
Citations

Biological Activity for PFK 15

PFK 15 is originally reported to be a selective PFKFB3 inhibitor (IC₅₀ = 207 nM); a more recent report failed to demonstrate activity in a PFKFB3 kinase assay. Selective for PFKFB3 over a panel of 96 kinases. Reduces glucose uptake and induces apoptosis in H522 lung adenocarcinoma and Jurkat T cell leukemia cells. Suppresses glucose uptake and tumor growth, and inhibits metastasis of Lewis lung carcinoma cell xenografts in mice.

Technical Data for PFK 15

M. Wt	260.29
Formula	C₁₇H₁₂N₂O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	4382-63-2
PubChem ID	25142799
InChi Key	UJJUKZPBUMCSJZ-BQYQJAHWSA-N
Smiles	O=C(/C=C/C2=CC=C(C=CC=C3)C3=N2)C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PFK 15

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	26.03	100

Preparing Stock Solutions for PFK 15

The following data is based on the product molecular weight 260.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.84 mL	19.21 mL	38.42 mL
5 mM	0.77 mL	3.84 mL	7.68 mL
10 mM	0.38 mL	1.92 mL	3.84 mL
50 mM	0.08 mL	0.38 mL	0.77 mL

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References for PFK 15

References are publications that support the biological activity of the product.

Brooke Targeting the Warburg effect in cancer; relationships for 2-arylpyridazinones as inhibitors of the key glycolytic enzyme 6-phosphofructo-2-kinase/2,6-bisphosphatase 3 (PFKFB3). Bioorg.Med.Chem. 2014 PMID: 24398380
Clem Targeting 6-phosphofructo-2-kinase (PFKFB3) as a therapeutic strategy against cancer. Mol.Cancer Ther. 2013 PMID: 23674815