PF 429242 dihydrochloride

Tocris Bioscience, part of Bio-Techne | Catalog # 3354

Competitive inhibitor of SREBP site 1 protease
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Key Product Details

Description

Competitive inhibitor of SREBP site 1 protease

View all SREBP Inhibitors »

Product Description

PF 429242 dihydrochloride is a reversible, competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). Selective for site 1 protease against a panel of serine proteases. Inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM). Also displays antiviral activity. Cell permeable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications

Molecular Weight

482.49

Formula

C25H35N3O2.2HCl

Storage

Desiccate at RT

Purity

≥97% (HPLC)

Chemical Name

4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide dihydrochloride

CAS Number

2248666-66-0

PubChem ID

90488837

InChI Key

GSUZWFZKTIOWTI-MQWQBNKOSA-N

SMILES

O=C(C2=CC=C(CN(CC)CC)C=C2)N(CCC3=CC=CC=C3OC)[C@@H]1CCNC1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 24.12 50
DMSO 24.12 50

Preparing Stock Solutions for PF 429242 dihydrochloride

The following data is based on the product molecular weight 482.49

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.15 mL 20.73 mL 41.45 mL
2.5 mM 0.83 mL 4.15 mL 8.29 mL
5 mM 0.41 mL 2.07 mL 4.15 mL
25 mM 0.08 mL 0.41 mL 0.83 mL

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Product Documents for PF 429242 dihydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 429242 dihydrochloride

For research use only

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