PF 3845
Tocris Bioscience, part of Bio-Techne | Catalog # 4175
Selective FAAH inhibitor
Key Product Details
Description
Selective FAAH inhibitor
Product Description
PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10 μM).Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
456.46
Formula
C24H23F3N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
CAS Number
1196109-52-0
PubChem ID
25154867
InChI Key
NBOJHRYUGLRASX-UHFFFAOYSA-N
SMILES
O=C(NC2=CN=CC=C2)N1CCC(CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3)CC1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.65 | 100 | |
| Ethanol | 22.82 | 50 |
Preparing Stock Solutions
for PF 3845
The following data is based on the product molecular weight 456.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.95 mL | 21.91 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 10 mM | 0.22 mL | 1.10 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ahn Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin.Drug Discov. 2009 PMID: 20544003
- Ahn Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem.Biol. 2009 PMID: 19389627
Product Specific Notices for PF 3845
For research use only
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