PF 3845

Name: PF 3845
Brand: Tocris Bioscience
SKU: 4175

Tocris Bioscience, part of Bio-Techne | Catalog # 4175

Citations (15)

COA / SDS

Selective FAAH inhibitor

Key Product Details

Description:	Selective FAAH inhibitor
Chemical Name:	N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	456.46

View Full Technical Details for PF 3845

Technical Data
Citations

Biological Activity for PF 3845

PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (K_i = 0.23 μM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC₅₀ >10 μM).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data for PF 3845

M. Wt	456.46
Formula	C₂₄H₂₃F₃N₄O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1196109-52-0
PubChem ID	25154867
InChi Key	NBOJHRYUGLRASX-UHFFFAOYSA-N
Smiles	O=C(NC2=CN=CC=C2)N1CCC(CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for PF 3845

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	45.65	100
	ethanol	22.82	50

Preparing Stock Solutions for PF 3845

The following data is based on the product molecular weight 456.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.19 mL	10.95 mL	21.91 mL
5 mM	0.44 mL	2.19 mL	4.38 mL
10 mM	0.22 mL	1.10 mL	2.19 mL
50 mM	0.04 mL	0.22 mL	0.44 mL

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References for PF 3845

References are publications that support the biological activity of the product.

Ahn Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin.Drug Discov. 2009 PMID: 20544003
Ahn Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem.Biol. 2009 PMID: 19389627