PF 3758309 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 6005
Potent PAK4 inhibitor; orally available
Product Description
PF 3758309 dihydrochloride is a potent PAK4 inhibitor (IC50 = 1.3 nM; Kd = 2.7 nM). Inhibits proliferation and anchorage-independent growth of a panel of tumor cell lines in vitro. Suppresses growth of human HCT116 and A549 tumor cell xenografts in mice. Orally available.Licensing Information
Sold for research purposes under agreement from Pfizer IncExternal Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3758309 is reviewed on the Chemical Probes website.Product Specifications
Molecular Weight
563.55
Formula
C25H30N8OS.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-[(1S)-2-(Dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[(2-methylthieno[3,2-d]pyrimidin-4-yl)amino]pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide dihydrochloride
PubChem ID
91885498
InChI Key
BTVSNRMSUYBDRT-JQDLGSOUSA-N
SMILES
CN(C[C@H](C1=CC=CC=C1)NC(N2CC3=C(C2(C)C)NN=C3NC4=C5SC=CC5=NC(C)=N4)=O)C.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 56.35 | 100 | |
| DMSO | 56.35 | 100 |
Preparing Stock Solutions
for PF 3758309 dihydrochloride
The following data is based on the product molecular weight 563.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.77 mL | 8.87 mL | 17.74 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.77 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Murray Small-molecule p21-activated kinase inhibitor PF-3758309 is a potent inhibitor of oncogenic signaling and tumor growth. Proc.Natl.Acad.Sci.U.S.A. 2010 PMID: 20439741
Product Specific Notices for PF 3758309 dihydrochloride
For research use only
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