PF 3644022
Tocris Bioscience, part of Bio-Techne | Catalog # 4279
Potent MK2 inhibitor
Product Description
PF 3644022 is a potent, ATP-competitive inhibitor of mitogen-activated protein kinase (MAPK)-activated protein kinase-2 (MK2) (IC50 = 5.2 nM; Ki = 3 nM). Inhibits tumor necrosis factor α (TNFα) production in U937 monocytic cells and peripheral blood mononuclear cells (PBMCs) (IC50 = 160 nM); exhibits oral efficacy in acute and chronic inflammatory models.Licensing Information
Sold for research purposes under agreement from Pfizer Inc.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of PF 3644022 is reviewed on the chemical probes website..Product Specifications
Molecular Weight
374.46
Formula
C21H18N4OS
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(10R)-9,10,11,12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1,4]diazepinothieno[3,2-f]quinolin-8-one
CAS Number
1276121-88-0
PubChem ID
44631903
InChI Key
CMWRPDHVGMHLSZ-GFCCVEGCSA-N
SMILES
O=C(N[C@H](C)CN4)C3=C4C1=C(S3)C=CC2=C1C=CC(C5=CC=C(C)N=C5)=N2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 14.98 | 40 |
Preparing Stock Solutions
for PF 3644022
The following data is based on the product molecular weight 374.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.4 mM | 6.68 mL | 33.38 mL | 66.76 mL |
| 2 mM | 1.34 mL | 6.68 mL | 13.35 mL |
| 4 mM | 0.67 mL | 3.34 mL | 6.68 mL |
| 20 mM | 0.13 mL | 0.67 mL | 1.34 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
Product Specific Notices for PF 3644022
For research use only
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